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Anti-PIRH2 Polyclonal Antibody
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Catalog No. TMAB-11465
Anti-PIRH2 Polyclonal Antibody is a Rabbit antibody targeting PIRH2. Anti-PIRH2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Anti-PIRH2 Polyclonal Antibody
Anti-PIRH2 Polyclonal Antibody
😃Good
Catalog No. TMAB-11465
Anti-PIRH2 Polyclonal Antibody is a Rabbit antibody targeting PIRH2. Anti-PIRH2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-PIRH2 Polyclonal Antibody is a Rabbit antibody targeting PIRH2. Anti-PIRH2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; FCM: 2μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Nucleus speckle. Cytoplasm. |
| Tissue Specificity | Detected in testis, liver, kidney and heart. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | PirH2 has ubiquitin-protein ligase activity. It binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53 (referenced from entrez gene).[SUBUNIT] Monomer and homodimer. [SUBCELLULAR LOCATION] Nucleus. Nucleus speckle. Cytoplasm. |
| Immunogen | KLH conjugated synthetic peptide: human PIRH2 |
| Antigen Species | Human |
| Gene Name | RCHY1 |
| Gene ID | |
| Protein Name | RING finger and CHY zinc finger domain-containing protein 1 |
| Uniprot ID | |
| Function | Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Contributes to the regulation of CDKN1B and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression. |
| Molecular Weight | Theoretical: 30 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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