Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell cycle in the G2/M phase.PARP-1-IN-3 may be useful for the study of cancer-related diseases. cancer-related diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 652.00 | |
50 mg | In stock | $ 913.00 | |
100 mg | In stock | $ 1,230.00 | |
500 mg | In stock | $ 2,460.00 |
Description | PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell cycle in the G2/M phase.PARP-1-IN-3 may be useful for the study of cancer-related diseases. cancer-related diseases. |
Targets&IC50 | PARP2:2.34 nM, DLD-1 cells:2.83 μM, HCT116 cells:0.30 μM, SW480 cells:33.69 μM, PARP1:0.25 nM, NCM460 cells:486.87 μM |
In vitro |
PARP-1-IN-3 (compound 13f) exhibits effective anticancer activity, with IC50 values of 0.30 μM, 2.83 μM, 33.69 μM, and 486.87 μM against HCT116, DLD-1, SW480, and NCM460 cells, respectively, after a 48-hour treatment[1]. In HCT116 cells, PARP-1-IN-3 (0.3-3 μM) inhibits colony formation and migration over a 24-48 hour period[1]. A 48-hour treatment with PARP-1-IN-3 (0.3-3 μM) induces the accumulation of DNA double-strand breaks in HCT116 cells[1]. Treatment with PARP-1-IN-3 (0.3-7.5 μM) for 48-72 hours leads to cell cycle arrest at the G2/M phase, reduces mitochondrial membrane potential, and ultimately induces apoptosis in HCT116 cells[1]. |
Molecular Weight | 425.28 |
Formula | C21H17BrN2O3 |
CAS No. | 2976342-33-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (235.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PARP-1-IN-3 2976342-33-1 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair PARP inhibitor inhibit