Shopping Cart
Remove All
Your shopping cart is currently empty
PROTAC ERRα ligand 1
Copy Product Info
😃Good
Catalog No. T15191Cas No. 1264754-13-3
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50 values of 0.04 μM for ERRα and 2.8 μM for ERRγ.
PROTAC ERRα ligand 1
Copy Product Info😃Good
Purity: 99.02%
Catalog No. T15191Cas No. 1264754-13-3
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50 values of 0.04 μM for ERRα and 2.8 μM for ERRγ.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | In Stock | In Stock | |
| 2 mg | $37 | In Stock | In Stock | |
| 5 mg | $58 | In Stock | In Stock | |
| 10 mg | $88 | In Stock | In Stock | |
| 25 mg | $157 | In Stock | In Stock | |
| 50 mg | $256 | In Stock | In Stock | |
| 100 mg | $383 | In Stock | In Stock | |
| 500 mg | $822 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $69 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.02%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
PROTAC ERRα ligand 1 AI Summary
PROTAC ERRα ligand 1 exhibits a wide range of bioactivities. It shows antagonist activity at 6his-tagged ERRalpha and ERRgamma LBDs, and agonist activity at ERRalpha and ERRbeta LBDs. The compound demonstrates significant inhibition of CYP2D6 and CYP3A4 enzymes, possesses good metabolic stability in liver microsomes, and moderate binding affinity to ERalpha and ERbeta. It has notable antiobesity effects in mouse models, reducing body fat, lean mass, insulin levels, and triglycerides. Additionally, it shows antidiabetic properties in ZDF fa/fa rat models, lowering blood glucose, triglycerides, and free fatty acids, and improving glucose tolerance. The compound is highly protein-bound, with 99.95% binding to plasma proteins in human plasma, which affects its distribution, metabolism, and elimination in the body.
Furthermore, PROTAC ERRα ligand 1 binds to GST-tagged ERRalpha-LBD using fluorescein-conjugated coactivator PGC-1alpha, showing an IC50 value of 33.0 nM, indicating potent inhibitory effects. It also exhibits some antiviral activity against SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of 6.3% at a 20 µM concentration. The compound shows moderate activity in inhibiting SARS-CoV-2-induced cytotoxicity in VERO-E6 cells with an inhibition of 16.67% at 10 µM concentration, an IC50 value greater than 33,000 nM, and a CC50 of 3330 nM, leading to a selectivity index of 0.1.
Overall, PROTAC ERRα ligand 1 demonstrates potential in various metabolic pathways related to obesity, diabetes, and has moderate antiviral activity against SARS-CoV-2..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50 values of 0.04 μM for ERRα and 2.8 μM for ERRγ. |
| Targets&IC50 | ERRγ:2.8 μM, ERRα:0.04 μM |
| Molecular Weight | 420.36 |
| Formula | C19H11F3N2O4S |
| Cas No. | 1264754-13-3 |
| Smiles | O(C1=C(C(F)(F)F)C=C(C#N)C=C1)C2=C(OC)C=C(/C=C\3/C(=O)NC(=O)S3)C=C2 |
| Relative Density. | 1.53 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (285.47 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.52 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy PROTAC ERRα ligand 1 | purchase PROTAC ERRα ligand 1 | PROTAC ERRα ligand 1 cost | order PROTAC ERRα ligand 1 | PROTAC ERRα ligand 1 chemical structure | PROTAC ERRα ligand 1 formula | PROTAC ERRα ligand 1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.