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Vaborbactam
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Catalog No. T17210Cas No. 1360457-46-0
Alias RPX7009
Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.
Vaborbactam
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Purity: 98.81%
Catalog No. T17210Alias RPX7009Cas No. 1360457-46-0
Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $142 | - | In Stock | |
| 5 mg | $325 | 5 days | 5 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.81%
Appearance:Solid
Color:White to Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections. |
| In vitro | The β-lactamase inhibitor vaborbactam can also form an acyl-enzyme complex with Pseudomonas aeruginosa PBP3. We found that vaborbactam inhibits PBP3 (IC50 of 262 μM), and its binding to PBP3 increases the protein thermal stability by about 2°C[1]. |
| In vivo | In a neutropenic mouse thigh infection model, the administration of 100 mg/kg meropenem alone and in combination with various doses of vaborbactam against Klebsiella pneumoniae was evaluated. The results showed that intraperitoneal injection of 300 mg/kg meropenem combined with 50 mg/kg vaborbactam resulted in the greatest reduction in bacterial counts compared to the untreated control group[2]. |
| Synonyms | RPX7009 |
| Molecular Weight | 297.14 |
| Formula | C12H16BNO5S |
| Cas No. | 1360457-46-0 |
| Smiles | OB1O[C@H](CC(O)=O)CC[C@@H]1NC(=O)Cc1cccs1 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Storage | store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | H2O: 2 mg/mL (6.73 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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