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Muscarinic M4 modulator-1
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Catalog No. T210673Cas No. 3082186-91-9
Muscarinic M4 modulator-1 is a positive allosteric modulator of the Muscarinic M4 receptor. It activates the muscarinic M4 receptor with allosteric efficacy (EC50) values of 14 nM in CHO-K1 cells and 3 nM in HEK293 cells. Muscarinic M4 modulator-1 exhibits antipsychotic-like activity and shows potential for research in psychiatric and/or neurological disorders.
Muscarinic M4 modulator-1
😃Good
Catalog No. T210673Cas No. 3082186-91-9
Muscarinic M4 modulator-1 is a positive allosteric modulator of the Muscarinic M4 receptor. It activates the muscarinic M4 receptor with allosteric efficacy (EC50) values of 14 nM in CHO-K1 cells and 3 nM in HEK293 cells. Muscarinic M4 modulator-1 exhibits antipsychotic-like activity and shows potential for research in psychiatric and/or neurological disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Muscarinic M4 modulator-1 is a positive allosteric modulator of the Muscarinic M4 receptor. It activates the muscarinic M4 receptor with allosteric efficacy (EC50) values of 14 nM in CHO-K1 cells and 3 nM in HEK293 cells. Muscarinic M4 modulator-1 exhibits antipsychotic-like activity and shows potential for research in psychiatric and/or neurological disorders. |
| In vitro | Muscarinic M4 modulator-1 (Example 4) exhibits allosteric efficacy on muscarinic M4 receptors with an EC50 of 14 nM in CHO-K1 cells and 3 nM in HEK293 cells (0.2-4 hours). |
| In vivo | Muscarinic M4 modulator-1 (Example 4), administered once via intraperitoneal injection at doses of 10 and 30 mg/kg in a rat model, showed receptor occupancy rates of 33.9% and 66.7%, respectively. |
| Molecular Weight | 412.44 |
| Formula | C21H22F2N6O |
| Cas No. | 3082186-91-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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