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SR-1114
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Catalog No. T81108Cas No. 2769141-82-2
SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
SR-1114
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Catalog No. T81108Cas No. 2769141-82-2
SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1]. |
| In vitro | Certainly, here is a revised version of the sentence: 'Ser nM TPP nM CUR (7)' is a chemical compound that exhibits specific activity, engaging in targeted interactions within a designated chemical or biological context. The notation encapsulates its unique structure and function. (Note: The sentence provided was incomplete and lacked context. I've crafted a general revision that addresses a typical description of chemical compound activity while retaining the original elements in parentheses and brackets. If there was additional information or specific jargon intended to be included, please provide the full sentence or context for more accurate assistance.) |
| In vivo | Ser nM TPP nM CUR (4 mg/kg; i.v. once) exhibits improved renal tissue distribution through KIM-1-receptor-mediated endocytosis within renal tubular epithelial cells, and it enhances the renal function in mice with acute kidney injury (AKI) [1]. |
| Molecular Weight | 830.86 |
| Formula | C39H42N8O11S |
| Cas No. | 2769141-82-2 |
| Smiles | O=C(NC1CCC1)C=2C=CC3=NC(=CN3C2)C=4C=CC=C(C4)NS(=O)(=O)NCCOCCOCCNC(=O)COC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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