Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
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Description | SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1]. |
In vitro |
Certainly, here is a revised version of the sentence: 'Ser nM TPP nM CUR (7)' is a chemical compound that exhibits specific activity, engaging in targeted interactions within a designated chemical or biological context. The notation encapsulates its unique structure and function. (Note: The sentence provided was incomplete and lacked context. I've crafted a general revision that addresses a typical description of chemical compound activity while retaining the original elements in parentheses and brackets. If there was additional information or specific jargon intended to be included, please provide the full sentence or context for more accurate assistance.) |
In vivo | Ser nM TPP nM CUR (4 mg/kg; i.v. once) exhibits improved renal tissue distribution through KIM-1-receptor-mediated endocytosis within renal tubular epithelial cells, and it enhances the renal function in mice with acute kidney injury (AKI) [1]. |
Molecular Weight | 830.86 |
Formula | C39H42N8O11S |
CAS No. | 2769141-82-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SR-1114 2769141-82-2 PROTAC PROTACs inhibitor inhibit