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PVRIG Protein, Cynomolgus, Recombinant (His)

Catalog No. TMPJ-00436
Synonyms: CD112R, C7orf15MGC138295, MGC104322, transmembrane protein PVRIG, MGC138297, PVRIG, C7orf15, MGC2463

PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PVRIG Protein, Cynomolgus, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 86.00
50 μg 5 days $ 262.00
500 μg 5 days $ 2,230.00
1 mg 5 days $ 3,350.00
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Biological Description
Technical Params
Product Properties
Description PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Species Cynomolgus
Expression System Human Cells
Tag C-6His
Accession Number A0A2K5WVV8
Synonyms CD112R, C7orf15MGC138295, MGC104322, transmembrane protein PVRIG, MGC138297, PVRIG, C7orf15, MGC2463
Amino Acid Thr41-Asp171
Construction Recombinant Cynomolgus Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 20-30 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

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Keywords

PVRIG Protein, Cynomolgus, Recombinant (His) MGC-2463 CD112R MGC 2463 C7orf15MGC138295 MGC104322 MGC 138297 transmembrane protein PVRIG MGC-138297 MGC138297 PVRIG MGC-104322 MGC 104322 C7orf15MGC-138295 C7orf15 MGC2463 C7orf15MGC 138295 recombinant recombinant-proteins proteins protein

 

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