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Oteseconazole

Name: Oteseconazole
Brand: TargetMol
SKU: T16412
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16412Cas No. 1340593-59-0

Alias VT-1161

Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM).

Oteseconazole

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Purity: 99.95%

Catalog No. T16412Alias VT-1161Cas No. 1340593-59-0

Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$93	In Stock	In Stock
2 mg	$137	In Stock	In Stock
5 mg	$228	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$569	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,070	-	In Stock
200 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$268	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Oteseconazole AI Summary

Oteseconazole exhibits potent antifungal activity against Candida albicans, Trichophyton rubrum, and Cryptococcus neoformans with MIC50 values of <= 0.001 ug/mL, 0.001 ug/mL, and 625.0 nM respectively. It demonstrates a high selectivity index (>65000.0) for inhibiting CYP3A4 in human hepatocytes and has a strong binding affinity (Kd <= 39.0 nM) for Candida albicans CYP51, with a selectivity ratio (>2200.0) for yeast CYP51 over human CYP51. The compound shows considerable metabolic stability (>99.0 %) in human liver microsomes after 2 hours and has a long half-life (>24.0 hr) after oral administration. In vivo, Oteseconazole effectively reduces kidney fungal burden by 99.0% in a mouse candidiasis model and shows 86.0% mycological efficacy in a guinea pig dermatophytosis model at an oral dose of 10 mg/kg. While Oteseconazole has low haemolytic activity (HC10 > 20.0 uM) and non-cytotoxicity to HEK293 cells (CC50 > 20000.0 nM), it does not exhibit significant antibacterial activity against several tested bacterial strains at MIC values above 20000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM).
Targets&IC50	CYP2C9:99 μM, CYP2C19:72 μM
Synonyms	VT-1161

Chemical Properties

Molecular Weight	527.39
Formula	C₂₃H₁₆F₇N₅O₂
Cas No.	1340593-59-0
Smiles	O[C@@](Cn1cnnn1)(c1ccc(F)cc1F)C(F)(F)c1ccc(cn1)-c1ccc(OCC(F)(F)F)cc1
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (474.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8961 mL	9.4806 mL	18.9613 mL	94.8065 mL
5 mM	0.3792 mL	1.8961 mL	3.7923 mL	18.9613 mL
10 mM	0.1896 mL	0.9481 mL	1.8961 mL	9.4806 mL
20 mM	0.0948 mL	0.4740 mL	0.9481 mL	4.7403 mL
50 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8961 mL
100 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.9481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc