Shopping Cart
Remove All
Your shopping cart is currently empty
AMY-101 TFA
(Synonyms: Cp40 TFA) Copy Product Info
🥰Excellent
Synonyms: Cp40 TFA
Catalog No. TP2139L Copy Product Info
Purity: 98.79%
🥰Excellent
AMY-101 TFA is a cyclic peptide that acts as an inhibitor of complement C3 and an immunomodulator, used for the treatment of gingivitis and periodontitis. It significantly reduces inflammation and lowers levels of MMP-8 and MMP-9. AMY-101 TFA also has a mitigating effect on lung inflammation/damage in patients with COVID-19-induced ARDS and acute kidney injury associated with SARS-CoV-2.
Cas No. 1789738-04-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $263 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:98.79%
Appearance:Solid
Color:White
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AMY-101 TFA is a cyclic peptide that acts as an inhibitor of complement C3 and an immunomodulator, used for the treatment of gingivitis and periodontitis. It significantly reduces inflammation and lowers levels of MMP-8 and MMP-9. AMY-101 TFA also has a mitigating effect on lung inflammation/damage in patients with COVID-19-induced ARDS and acute kidney injury associated with SARS-CoV-2. |
| Targets & IC50 | C3:0.5 nM (kd) |
| In vivo | Methods Mice were treated with AMY-101 TFA (4 mg/kg, subcutaneously, every 24 hours for 28 days) to test whether AMY-101 TFA is effective when administered systemically. Results: AMY-101 TFA resulted in a significant and sustained reduction in PPD, a measure of tissue damage. [1] |
| Synonyms | Cp40 TFA |
| Animal Research | Animal Model: Fifteen adult male cynomolgus monkeys (7–15 years old; 5.0–7.6 kg). Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution. Administration: Injected locally (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment) [1]. |
| Molecular Weight | 1903.11 |
| Formula | C85H118F3N23O20S2 |
| Cas No. | 1789738-04-0 |
| Smiles | C(C(O)=O)(F)(F)F.C(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(=O)N(C)CC(=O)N[C@@H](C)C(=O)N[C@@H](CC6=CN=CN6)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(N([C@@H]([C@H](CC)C)C(N)=O)C)=O)CSSC[C@H](NC([C@@H](NC([C@@H](CC7=CC=C(O)C=C7)N)=O)[C@H](CC)C)=O)C(=O)N[C@@H]([C@@H](C)C)C(=O)N3 |
| Relative Density. | no data available |
| Sequence | H-{D-Tyr}-Ile-Cys-Val-Trp(Me)-Gln-Asp-Trp-Sar-Ala-His-Arg-Cys-N(Me)Ile-NH₂ (Disulfide bridge:Cys3-Cys13) |
| Sequence Short | YICVWQDWXAHRCI |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: AMY-101 TFA chemical structure | AMY-101 TFA in vivo | AMY-101 TFA formula | AMY-101 TFA molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.