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AMY-101 TFA

🥰Excellent
Catalog No. TP2139LCas No. 1789738-04-0
Alias Cp40 TFA

AMY-101 TFA is a cyclic peptide that acts as an inhibitor of complement C3 and an immunomodulator, used for the treatment of gingivitis and periodontitis. It significantly reduces inflammation and lowers levels of MMP-8 and MMP-9. AMY-101 TFA also has a mitigating effect on lung inflammation/damage in patients with COVID-19-induced ARDS and acute kidney injury associated with SARS-CoV-2.

AMY-101 TFA
Other Forms of AMY-101 TFA:

AMY-101 TFA

🥰Excellent
Catalog No. TP2139LAlias Cp40 TFACas No. 1789738-04-0
AMY-101 TFA is a cyclic peptide that acts as an inhibitor of complement C3 and an immunomodulator, used for the treatment of gingivitis and periodontitis. It significantly reduces inflammation and lowers levels of MMP-8 and MMP-9. AMY-101 TFA also has a mitigating effect on lung inflammation/damage in patients with COVID-19-induced ARDS and acute kidney injury associated with SARS-CoV-2.
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1 mg$98In Stock
5 mg$263In Stock
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Product Introduction

Bioactivity
Description
AMY-101 TFA is a cyclic peptide that acts as an inhibitor of complement C3 and an immunomodulator, used for the treatment of gingivitis and periodontitis. It significantly reduces inflammation and lowers levels of MMP-8 and MMP-9. AMY-101 TFA also has a mitigating effect on lung inflammation/damage in patients with COVID-19-induced ARDS and acute kidney injury associated with SARS-CoV-2.
Targets&IC50
C3:0.5 nM (kd)
In vivo
Methods Mice were treated with AMY-101 TFA (4 mg/kg, subcutaneously, every 24 hours for 28 days) to test whether AMY-101 TFA is effective when administered systemically.
Results: AMY-101 TFA resulted in a significant and sustained reduction in PPD, a measure of tissue damage. [1]
Animal Research
Animal Model: Fifteen adult male cynomolgus monkeys (7–15 years old; 5.0–7.6 kg).
Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration: Injected locally (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment) [1].
SynonymsCp40 TFA
Chemical Properties
Molecular Weight1903.11
FormulaC85H118F3N23O20S2
Cas No.1789738-04-0
SmilesC(C(O)=O)(F)(F)F.C(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(=O)N(C)CC(=O)N[C@@H](C)C(=O)N[C@@H](CC6=CN=CN6)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(N([C@@H]([C@H](CC)C)C(N)=O)C)=O)CSSC[C@H](NC([C@@H](NC([C@@H](CC7=CC=C(O)C=C7)N)=O)[C@H](CC)C)=O)C(=O)N[C@@H]([C@@H](C)C)C(=O)N3
Relative Density.no data available
Sequence ShortYICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

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