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NFAT Transcription Factor Regulator-1
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Catalog No. T12218Cas No. 245747-71-1
NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.
NFAT Transcription Factor Regulator-1
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Purity: 99.90%
Catalog No. T12218Cas No. 245747-71-1
NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $39 | - | In Stock | |
| 5 mg | $85 | - | In Stock | |
| 10 mg | $145 | - | In Stock | |
| 25 mg | $269 | - | In Stock | |
| 50 mg | $397 | - | In Stock | |
| 100 mg | $568 | - | In Stock | |
| 500 mg | $1,130 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $94 | - | In Stock |
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Purity:99.90%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM. |
| Targets&IC50 | IL-2 synthesis:182 nM |
| In vitro | NFAT Transcription Factor Regulator-1 inhibits IL-2 synthesis(IC50 of 182 nM). NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release. |
| In vivo | NFAT Transcription Factor Regulator-1 demonstrates an inhibitory potency on T-cell IL-2 production that is approximately 10 times greater than cyclosporine, requiring doses of 3.0 mg/kg and 30 mg/kg, respectively, for comparable effects. In vivo studies in monkeys further reveal the potential of NFAT Transcription Factor Regulator-1 to block T-cell cytokine production effectively, suggesting its viability as a transplantation aid comparable to cyclosporine[1]. |
| Molecular Weight | 416.28 |
| Formula | C17H10F6N4O2 |
| Cas No. | 245747-71-1 |
| Smiles | FC(F)Oc1cc(nn1-c1ccc(NC(=O)c2ccncc2F)cc1)C(F)(F)F |
| Relative Density. | 1.53 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (120.11 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.01 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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