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NUCC-390

Name: NUCC-390
Brand: TargetMol
SKU: T12269
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12269Cas No. 1060524-97-1

NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodegeneration in vivo.

NUCC-390

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Purity: 97.08%

Catalog No. T12269Cas No. 1060524-97-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$812	-	In Stock
50 mg	$1,130	-	In Stock
100 mg	$1,520	-	In Stock
200 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$297	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.08%

Appearance:Oil

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodegeneration in vivo.
In vitro	NUCC-390 (10 μM) elicits a strong (Ca)i response, which can be blocked by the potent and selective CXCR4 antagonist AMD3100. Pre-treatment with NUCC-390 (10 μM; 30 mins) increases pERK levels, stimulating signaling activity downstream of CXCR4 receptors. NUCC-390 (10 μM; 2 hours) induces CXCR4 receptor internalization, while non-treated cells show diffuse CXCR4-YFP expression in the cytosol and clear membrane expression in HEK cells[1]. Additionally, NUCC-390 (0-1.25 μM; 24 hours) enhances axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].
In vivo	NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) enhances functional and anatomical recovery of the neuromuscular junction (NMJ) after acute nerve terminal damage by α-LTx in CD-1 mice[2].

Chemical Properties

Molecular Weight	395.54
Formula	C₂₃H₃₃N₅O
Cas No.	1060524-97-1
Smiles	C(=O)(C=1C2=C(N(CCC)N1)CCC(NCCC=3C=CN=CC3)C2)N4CCCCC4
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (151.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5282 mL	12.6409 mL	25.2819 mL	126.4095 mL
5 mM	0.5056 mL	2.5282 mL	5.0564 mL	25.2819 mL
10 mM	0.2528 mL	1.2641 mL	2.5282 mL	12.6409 mL
20 mM	0.1264 mL	0.6320 mL	1.2641 mL	6.3205 mL
50 mM	0.0506 mL	0.2528 mL	0.5056 mL	2.5282 mL
100 mM	0.0253 mL	0.1264 mL	0.2528 mL	1.2641 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc