Shopping Cart

Your shopping cart is currently empty

Raphin1

Name: Raphin1
Brand: TargetMol
SKU: T7820
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T7820Cas No. 2022961-17-5

Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).

Raphin1

Copy Product Info

😃Good

Purity: 99.39%

Catalog No. T7820Cas No. 2022961-17-5

Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$46	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$125	In Stock	In Stock
100 mg	$188	In Stock	In Stock
200 mg	$275	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.39%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Raphin1 AI Summary

Raphin1 exhibits a diverse range of bioactivities. It has cytotoxic activity against NIH3T3 cells with an EC50 > 60000.0 nM and demonstrates potency in various assays. It functions as a lipid storage modulator, inhibits Trypanosoma cruzi replication, L3MBTL1, chronic active B-cell receptor signaling, Histone Lysine Methyltransferase G9a, and various viruses including Lassa Virus and Marburg Virus. It also acts as an antagonist of the Neuropeptide S receptor, an inverse agonist for the GLP-1 receptor, and a small molecule activator of BRCA1 expression. Additionally, it induces synthetic lethality in tumor cells and antagonizes cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1). The compound also exhibits inhibitory activity against amino-terminal MBP-tagged/carboxy-terminal His6-tagged human PPP1R15A and PPP1R15B with IC50 values of 977.0 nM and 33.0 nM, respectively, and inhibits MELK with an IC50 of 200.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
Targets&IC50	R15B-PP1c holophosphatase:Kd：33 nM

Chemical Properties

Molecular Weight	231.08
Formula	C₈H₈Cl₂N₄
Cas No.	2022961-17-5
Smiles	NC(=N)N\N=C\c1cccc(Cl)c1Cl
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (540.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (17.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3275 mL	21.6375 mL	43.2751 mL	216.3753 mL
5 mM	0.8655 mL	4.3275 mL	8.6550 mL	43.2751 mL
10 mM	0.4328 mL	2.1638 mL	4.3275 mL	21.6375 mL
20 mM	0.2164 mL	1.0819 mL	2.1638 mL	10.8188 mL
50 mM	0.0866 mL	0.4328 mL	0.8655 mL	4.3275 mL
100 mM	0.0433 mL	0.2164 mL	0.4328 mL	2.1638 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc