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VU0155056 is a dual PLD1/2 inhibitor with IC50 = 81 nM for PLD1 and IC50 = 240 nM for PLD2 in in vitro assays, and IC50 < 1 µM in cellular assays, which inhibits breast cancer cell invasion.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | In Stock | |
5 mg | $722 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock |
Description | VU0155056 is a dual PLD1/2 inhibitor with IC50 = 81 nM for PLD1 and IC50 = 240 nM for PLD2 in in vitro assays, and IC50 < 1 µM in cellular assays, which inhibits breast cancer cell invasion. |
In vitro | VU0155056 was tested in HEK293, PC12, and human neutrophil models at concentrations ranging from 0.5 to 20 μM for 10 minutes to 24 hours. VU0155056 significantly reduced levels of phosphatidic acid (PA) and phosphatidylbutanol (PBut), indicating effective inhibition of PLD1 and PLD2 activity. [1] |
Alias | VU 0155056 |
Molecular Weight | 414.5 |
Formula | C25H26N4O2 |
Cas No. | 1130067-18-3 |
Smiles | O=C(NCCN1CCC(N2C(=O)NC=3C=CC=CC32)CC1)C=4C=CC=5C=CC=CC5C4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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