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CCL2 Protein, Rat, Recombinant (His)

(Synonyms: Small-inducible cytokine A2, Scya2, Monocyte chemotactic protein 1, Monocyte chemoattractant protein 1, MCP-1, Ccl2, C-C motif chemokine 2) Copy Product Info

Synonyms: Small-inducible cytokine A2, Scya2, Monocyte chemotactic protein 1, Monocyte chemoattractant protein 1, MCP-1, Ccl2, C-C motif chemokine 2

Catalog No. TMPJ-00852 Copy Product Info
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the cognate receptor CCR2, and together this signaling pair has been shown to have multiple pro-tumorigenic roles, from mediating tumor growth and angiogenesis to recruiting and usurping host stromal cells to support tumor progression. CCL2 is found in the circulation, where it has been suggested as a diagnostic biomarker of breast cancer and prostate cancer. CCL2 can also induce arachidonic acid release in human monocytes, which has been shown to be involved in adhesion and induction of the chemotactic response, in a pertussis-toxinsensitive manner.
Pack SizePriceUSA StockGlobal StockQuantity
5 μg$112-In Stock
10 μg$183-In Stock
20 μg$2927-10 days7-10 days
50 μg$5427-10 days7-10 days
100 μg$8397-10 days7-10 days
200 μg$1,2807-10 days7-10 days
500 μg$2,3307-10 days7-10 days
1 mg$3,4907-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Appearance:Lyophilized powder
Color:White
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Product Introduction

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the cognate receptor CCR2, and together this signaling pair has been shown to have multiple pro-tumorigenic roles, from mediating tumor growth and angiogenesis to recruiting and usurping host stromal cells to support tumor progression. CCL2 is found in the circulation, where it has been suggested as a diagnostic biomarker of breast cancer and prostate cancer. CCL2 can also induce arachidonic acid release in human monocytes, which has been shown to be involved in adhesion and induction of the chemotactic response, in a pertussis-toxinsensitive manner.
Species
Rat
Expression System
HEK293 Cells
TagC-6xHis
Accession NumberP14844
Amino AcidGln24-Asn148
ConstructionGln24-Asn148
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
SynonymsSmall-inducible cytokine A2, Scya2, Monocyte chemotactic protein 1, Monocyte chemoattractant protein 1, MCP-1, Ccl2, C-C motif chemokine 2
Research Background
Chemical Properties
Molecular Weight27-37 kDa (reducing condition)
Storage & Solubility Information
StorageLyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: CCL2 Protein, Rat, Recombinant (His) chemical structure | CCL2 Protein, Rat, Recombinant (His) molecular weight