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HPi1

Name: HPi1
Brand: TargetMol
SKU: T15500
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15500Cas No. 13080-21-2

HPi1 is a selective and orally active antimicrobial against Helicobacter pylori (IC50: 0.24 μM and a MIC of 0.08-0.16 μg/mL). HPi1 is inactive against other Xaliproden, including the gut commensals, Lactobacillus reuteri, Lactobacillus casei, and Bifidobacterium longum.

HPi1

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Purity: 98.8%

Catalog No. T15500Cas No. 13080-21-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$83	In Stock	In Stock
100 mg	$117	In Stock	In Stock
200 mg	$176	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.8%

Appearance:solid

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HPi1 is a selective and orally active antimicrobial against Helicobacter pylori (IC50: 0.24 μM and a MIC of 0.08-0.16 μg/mL). HPi1 is inactive against other Xaliproden, including the gut commensals, Lactobacillus reuteri, Lactobacillus casei, and Bifidobacterium longum.
Targets&IC50	Antibacterial:(MIC)0.08-0.16 μg/ml(Helicobacter pylori), Antibacterial:0.24 μM
In vitro	HPi1 demonstrates efficacy against clarithromycin-resistant H. pylori strains ARHp172 (with a minimum inhibitory concentration (MIC) of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL). Although HPi1 is somewhat effective against Bacteroides species, the required concentration is significantly higher (at least 18 times) than for inhibiting H. pylori. The compound possesses favorable physicochemical and pharmacological characteristics, including an aqueous solubility of 19 μg/mL, 93% human plasma protein binding, a half-life of 1.3 hours in the presence of human liver microsomes, and the capacity for passive membrane permeation. Its MIC values against various H. pylori isolates range from 0.002 to 0.032 μg/mL (0.01 to 0.17 μM) according to agar dilution assays, indicating broad activity. Additionally, HPi1 exhibits even stronger activity against Campylobacter jejuni, with a MIC of 0.3 μg/mL.
In vivo	Treated with HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice), reduces colony counts below the limit of detection at doses of 25 or 50 mg/kg/day.

Chemical Properties

Molecular Weight	192.24
Formula	C₈H₈N₄S
Cas No.	13080-21-2
Smiles	NNC1=NC2=CC=CC=C2NC1=S
Relative Density.	1.55 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (312.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2018 mL	26.0092 mL	52.0183 mL	260.0916 mL
5 mM	1.0404 mL	5.2018 mL	10.4037 mL	52.0183 mL
10 mM	0.5202 mL	2.6009 mL	5.2018 mL	26.0092 mL
20 mM	0.2601 mL	1.3005 mL	2.6009 mL	13.0046 mL
50 mM	0.1040 mL	0.5202 mL	1.0404 mL	5.2018 mL
100 mM	0.0520 mL	0.2601 mL	0.5202 mL	2.6009 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc