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Branaplam (LMI070; NVS-SM1) hydrochloride is a selective, orally active SMN2 splicing modulator that acts on SMN (EC50: 20 nM) and inhibits hERG (IC50: 6.3 μM). In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride increased full-length SMN protein and improved survival.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $83 | In Stock | |
10 mg | $118 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $293 | In Stock | |
100 mg | $433 | In Stock | |
200 mg | $642 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Branaplam (LMI070; NVS-SM1) hydrochloride is a selective, orally active SMN2 splicing modulator that acts on SMN (EC50: 20 nM) and inhibits hERG (IC50: 6.3 μM). In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride increased full-length SMN protein and improved survival. |
Molecular Weight | 429.95 |
Formula | C22H28ClN5O2 |
Cas No. | 1562338-39-9 |
Color | Yellow |
Appearance | Solid |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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