Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Branaplam hydrochloride

🥰Excellent
Catalog No. T62381Cas No. 1562338-39-9
Alias NVS-SM1 hydrochloride, LMI070 hydrochloride, LMI 070 hydrochloride

Branaplam hydrochloride (LMI070; NVS-SM1) is a selective and orally active SMN2 splicing modulator that acts directly on SMN with an EC50 value of 20 nM. Branaplam hydrochloride also inhibits hERG channels, demonstrating an IC50 of 6.3 μM. In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride significantly increased full-length SMN protein levels and markedly improved survival.

Branaplam hydrochloride

Branaplam hydrochloride

🥰Excellent
Purity: 98.45%
Catalog No. T62381Alias NVS-SM1 hydrochloride, LMI070 hydrochloride, LMI 070 hydrochlorideCas No. 1562338-39-9
Branaplam hydrochloride (LMI070; NVS-SM1) is a selective and orally active SMN2 splicing modulator that acts directly on SMN with an EC50 value of 20 nM. Branaplam hydrochloride also inhibits hERG channels, demonstrating an IC50 of 6.3 μM. In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride significantly increased full-length SMN protein levels and markedly improved survival.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$83In Stock
10 mg$118In Stock
25 mg$198In Stock
50 mg$293In Stock
100 mg$433In Stock
200 mg$642In Stock
1 mL x 10 mM (in DMSO)$98In Stock
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Batch Information

Select Batch
Purity:98.45%
Contact us for more batch information

Resource Download

Product Introduction

Bioactivity
Description
Branaplam hydrochloride (LMI070; NVS-SM1) is a selective and orally active SMN2 splicing modulator that acts directly on SMN with an EC50 value of 20 nM. Branaplam hydrochloride also inhibits hERG channels, demonstrating an IC50 of 6.3 μM. In a mouse model of severe spinal muscular atrophy (SMA), Branaplam hydrochloride significantly increased full-length SMN protein levels and markedly improved survival.
Targets&IC50
SMN:20 nM (EC50), ERG (human):6.3 μM
In vitro
In Homo sapiens fibroblasts, Branaplam hydrochloride caused changes in the expression levels of 175 genes. [1]
In vivo
After oral administration of Branaplam hydrochloride (3, 10, 30 mg/kg), the SMN2-FL transcript and SMN protein levels in the brain and spinal cord of mice showed a dose-dependent increase [1].
SynonymsNVS-SM1 hydrochloride, LMI070 hydrochloride, LMI 070 hydrochloride
Chemical Properties
Molecular Weight429.95
FormulaC22H28ClN5O2
Cas No.1562338-39-9
SmilesCl.OC1=CC(=CC=C1C=2N=NC(OC3CC(NC(C)(C)C3)(C)C)=CC2)C=4C=NNC4
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: <1mg/mL (Insoluble)
DMSO: 200 mg/mL (465.17 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3259 mL11.6293 mL23.2585 mL116.2926 mL
5 mM0.4652 mL2.3259 mL4.6517 mL23.2585 mL
10 mM0.2326 mL1.1629 mL2.3259 mL11.6293 mL
20 mM0.1163 mL0.5815 mL1.1629 mL5.8146 mL
50 mM0.0465 mL0.2326 mL0.4652 mL2.3259 mL
100 mM0.0233 mL0.1163 mL0.2326 mL1.1629 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Branaplam hydrochloride | purchase Branaplam hydrochloride | Branaplam hydrochloride cost | order Branaplam hydrochloride | Branaplam hydrochloride chemical structure | Branaplam hydrochloride in vivo | Branaplam hydrochloride in vitro | Branaplam hydrochloride formula | Branaplam hydrochloride molecular weight