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INNO-220
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Catalog No. T211026Cas No. 3032576-92-1
INNO-220 is a molecular glue degrader targeting CK1α, exhibiting oral activity and CRBN dependency, capable of inducing cell cycle arrest at G0/G1 phase and apoptosis. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibits the NF-κB signaling pathway, and activates the p53 pathway, making it suitable for lymphoma research.
INNO-220
😃Good
Purity: 98.95%
Catalog No. T211026Cas No. 3032576-92-1
INNO-220 is a molecular glue degrader targeting CK1α, exhibiting oral activity and CRBN dependency, capable of inducing cell cycle arrest at G0/G1 phase and apoptosis. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibits the NF-κB signaling pathway, and activates the p53 pathway, making it suitable for lymphoma research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $170 | - | In Stock | |
| 10 mg | $272 | - | In Stock | |
| 25 mg | $544 | - | In Stock | |
| 50 mg | $871 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.95%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | INNO-220 is a molecular glue degrader targeting CK1α, exhibiting oral activity and CRBN dependency, capable of inducing cell cycle arrest at G0/G1 phase and apoptosis. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibits the NF-κB signaling pathway, and activates the p53 pathway, making it suitable for lymphoma research. |
| In vitro | INNO-220 (0.0001–10 μM, 72 h) exhibited broad-spectrum antiproliferative activity against wild-type p53 lymphoma cells [1]. INNO-220 (50 nM, 8 h) modulates the p53/NF-κB signaling pathway in OCI-Ly3 and Z-138 cells[1]. INNO-220 (2–1250 nM, 6–24 h) activates p53 by degrading CK1α in OCI-Ly3 cells, Z-138 cells, and OCI-Ly19 cells[1]. |
| In vivo | INNO-220 (3–20 mg/kg, i.g., daily for 43 days) induced tumor regression in DLBCL and MCL xenograft models, inhibited NF-κB activity, and caused no significant changes in mouse body weight [1]. |
| Molecular Weight | 400.43 |
| Formula | C23H20N4O3 |
| Cas No. | 3032576-92-1 |
| Smiles | O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2)C=4C=NN(C4C=5C=CC=CC5)C)CC1 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (4.99 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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