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UB-221
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Catalog No. T9901A-1750Cas No. 2755114-30-6
UB-221 is a humanized IgG1 monoclonal antibody inhibitor that targets IgE. It significantly reduces IgE synthesis by stabilizing the membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated activation and degranulation of basophils. UB-221 lowers IgE levels in cynomolgus monkeys and human IgE (ε, κ) transgenic (hIGHE knock-in) mice, making it relevant for asthma and chronic spontaneous urticaria (CSU) research.
UB-221
UB-221
😃Good
Catalog No. T9901A-1750Cas No. 2755114-30-6
UB-221 is a humanized IgG1 monoclonal antibody inhibitor that targets IgE. It significantly reduces IgE synthesis by stabilizing the membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated activation and degranulation of basophils. UB-221 lowers IgE levels in cynomolgus monkeys and human IgE (ε, κ) transgenic (hIGHE knock-in) mice, making it relevant for asthma and chronic spontaneous urticaria (CSU) research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | UB-221 is a humanized IgG1 monoclonal antibody inhibitor that targets IgE. It significantly reduces IgE synthesis by stabilizing the membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated activation and degranulation of basophils. UB-221 lowers IgE levels in cynomolgus monkeys and human IgE (ε, κ) transgenic (hIGHE knock-in) mice, making it relevant for asthma and chronic spontaneous urticaria (CSU) research. |
| Cas No. | 2755114-30-6 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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