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Synucleozid hydrochloride
🥰Excellent
Catalog No. T13049LCas No. 2741856-68-6
Alias Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochloride
Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.
Synucleozid hydrochloride
🥰Excellent
Purity: 98.13%
Catalog No. T13049LAlias Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochlorideCas No. 2741856-68-6
Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.13%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease. |
| Targets&IC50 | SNCA IRE RNA:1.5 μM |
| In vitro | b>METHODS: The affinity of Synucleozid (100 nM-100 μM) for its putative binding site A in the IRE was measured by using a fluorescent adenine analog to 2-aminopurine (2-AP). RESULTS: Synucleozid reduced 2-AP emission with an EC50 of 2.7 ± 0.4 μM; importantly, restoration of 2-AP emission was observed as a function of the concentration of unlabeled SNCA IRE RNA (RNA-0), providing a competitive Kd value of 1.5 ± 0.3 μM. [1] |
| Synonyms | Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochloride |
| Molecular Weight | 404.9 |
| Formula | C22H21ClN6 |
| Cas No. | 2741856-68-6 |
| Smiles | Cl.N=C(N)C1=CC=C(C=C1)NC=2C=CC(=CC2)C3=CC4=CC=C(C=C4N3)C(=N)N |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (246.97 mM), Sonication is recommended. H2O: 1 mg/mL (2.47 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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