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Synucleozid hydrochloride

Name: Synucleozid hydrochloride
Brand: TargetMol
SKU: T13049L
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13049LCas No. 2741856-68-6

Alias Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochloride

Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.

Synucleozid hydrochloride

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Purity: 98.13%

Catalog No. T13049LAlias Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochlorideCas No. 2741856-68-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.13%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA. Synucleozid hydrochloride targets the IRE structure and inhibits SNCA translation in cells, and can be used to study Alzheimer's disease.
Targets&IC50	SNCA IRE RNA:1.5 μM
In vitro	b>METHODS: The affinity of Synucleozid (100 nM-100 μM) for its putative binding site A in the IRE was measured by using a fluorescent adenine analog to 2-aminopurine (2-AP). RESULTS: Synucleozid reduced 2-AP emission with an EC50 of 2.7 ± 0.4 μM; importantly, restoration of 2-AP emission was observed as a function of the concentration of unlabeled SNCA IRE RNA (RNA-0), providing a competitive Kd value of 1.5 ± 0.3 μM. [1]
Synonyms	Synucleozid hydrochloride (502139-01-7 free base), NSC-377363 hydrochloride, NSC377363 hydrochloride, NSC 377363 hydrochloride

Chemical Properties

Molecular Weight	404.9
Formula	C₂₂H₂₁ClN₆
Cas No.	2741856-68-6
Smiles	Cl.N=C(N)C1=CC=C(C=C1)NC=2C=CC(=CC2)C3=CC4=CC=C(C=C4N3)C(=N)N

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (246.97 mM), Sonication is recommended.

H2O: 1 mg/mL (2.47 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4697 mL	12.3487 mL	24.6975 mL	123.4873 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4939 mL	2.4697 mL	4.9395 mL	24.6975 mL
10 mM	0.2470 mL	1.2349 mL	2.4697 mL	12.3487 mL
20 mM	0.1235 mL	0.6174 mL	1.2349 mL	6.1744 mL
50 mM	0.0494 mL	0.2470 mL	0.4939 mL	2.4697 mL
100 mM	0.0247 mL	0.1235 mL	0.2470 mL	1.2349 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc