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Liothyronine

Liothyronine
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
Catalog No. T1653Cas No. 6893-02-3
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Purity:99.28%
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Liothyronine

Catalog No. T1653Cas No. 6893-02-3

Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
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Pack SizePriceAvailabilityQuantity
50 mg$36In Stock
100 mg$50In Stock
200 mg$71In Stock
500 mg$119In Stock
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Product Introduction

Bioactivity
Description
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
In vitro
Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells. High liothyronine levels induces a low TRalpha1:TRalpha2 ratio which can protect the cell from excessive triiodothyronine-induced gene expression[1].
AliasTresitope, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Triiodothyronine, L-3,3',5-Triiodothyronine, 3,3',5-Triiodo-L-thyronine, Lyothyronine
Chemical Properties
Molecular Weight650.97
FormulaC15H12I3NO4
Cas No.6893-02-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4.95 mg/mL (7.6 mM), Working solution is recommended to be prepared and used immediately.
DMSO: 1 mg/mL, Sonication is recommended.
Solution Preparation Table
10% DMSO+40% PEG300+5% Tween 80+45% Saline
1mg5mg10mg50mg
1 mM1.5362 mL7.6808 mL15.3617 mL76.8085 mL
5 mM0.3072 mL1.5362 mL3.0723 mL15.3617 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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