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PFI-2

Name: PFI-2
Brand: TargetMol
SKU: T1987
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1987Cas No. 1627676-59-8

Alias PFI2, PFI 2, (R)-PFI-2

PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

PFI-2

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Purity: 99.38%

Catalog No. T1987Alias PFI2, PFI 2, (R)-PFI-2Cas No. 1627676-59-8

PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

Pack Size	Price	Availability
5 mg	$83	In Stock
10 mg	$131	In Stock
25 mg	$254	In Stock
50 mg	$448	In Stock
100 mg	$807	In Stock

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Purity:99.38%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Targets&IC50	SETD7:2 nM
In vivo	In the cellular environment, through direct interaction with SETD7, PFI-2 affects Yes-associated protein localization in Hippo pathway signaling and the putative phenotype Setd7 gene deletion. The inhibitory activity of (R)-PFI-2 on human SETD7 was 500-fold higher than that of its isomer, (S)-PFI-2.
Synonyms	PFI2, PFI 2, (R)-PFI-2

Chemical Properties

Molecular Weight	499.52
Formula	C₂₃H₂₅F₄N₃O₃S
Cas No.	1627676-59-8
Smiles	FC1=C2C(=CC(S(N[C@H](CC3=CC(C(F)(F)F)=CC=C3)C(=O)N4CCCC4)(=O)=O)=C1)CCNC2
Relative Density.	1.371 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 66 mg/mL (132.12 mM), Heating is recommended.

DMSO: 100 mg/mL (200.19 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0019 mL	10.0096 mL	20.0192 mL	100.0961 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL	20.0192 mL
10 mM	0.2002 mL	1.0010 mL	2.0019 mL	10.0096 mL
20 mM	0.1001 mL	0.5005 mL	1.0010 mL	5.0048 mL
50 mM	0.0400 mL	0.2002 mL	0.4004 mL	2.0019 mL
100 mM	0.0200 mL	0.1001 mL	0.2002 mL	1.0010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc