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Tizanidine hydrochloride

Name: Tizanidine hydrochloride
Brand: TargetMol
SKU: T0290
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0290Cas No. 64461-82-1

Alias Tizanidine HCl, DS 103-282

Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons.

Tizanidine hydrochloride

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Purity: 99.96%

Catalog No. T0290Alias Tizanidine HCl, DS 103-282Cas No. 64461-82-1

Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$47	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$87	In Stock	In Stock
100 mg	$107	In Stock	In Stock
200 mg	$135	In Stock	In Stock
500 mg	$223	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Tizanidine hydrochloride AI Summary

Tizanidine hydrochloride is a multifaceted bioactive agent displaying diverse pharmacological effects across various biological targets. It acts as an inhibitor of several enzymes, with notable potencies: AmpC Beta-Lactamase (5623.4 nM), BAZ2B (707.9 nM), delayed death in the malarial parasite plastid (11689.1 nM), and Polymerase Iota (31622.8 nM). Additionally, Tizanidine hydrochloride induces DNA re-replication in MCF 10a normal breast cells (4.1 nM) and SW480 colon adenocarcinoma cells (259.3 nM). The compound’s antiviral activity against SARS-CoV-2 is limited, showing minimal inhibition effects on viral-induced cytotoxicity in various cell lines, including Caco-2 and VERO-6 cells, with slight inhibition percentages at 10-20 μM concentrations. It exhibits low efficacy in SARS-CoV-2 3CL-Pro protease inhibition and an overall lack of positive impact on cell viability against SARS-CoV-2. In terms of antimicrobial properties, Tizanidine hydrochloride exhibits mild antibacterial activity, inhibiting the growth of Escherichia coli (6.6%), Klebsiella pneumoniae (10.36%), Pseudomonas aeruginosa (18.39%), and Acinetobacter baumannii (4.87%), while showing negligible or negative effects on Candida albicans, Cryptococcus neoformans, and Staphylococcus aureus MRSA. The compound's effects on cell viability are cell type-dependent, influencing growth rates in assays involving U2OS, human fibroblasts, and HEK293T cells variably. It also affects the thermal stability of different protein domains, suggesting a modulatory effect on protein conformation and stability, with observed changes ranging from -1.91°C to +1.21°C. Furthermore, Tizanidine hydrochloride demonstrates diverse interactions with GPCR targets, affecting beta-arrestin recruitment. It inhibits receptors such as GPR119, GLP1R, and FPR2 while activating others like ADRA2A and AGTR1, indicating its broad and variable receptor modulatory capabilities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons.
Synonyms	Tizanidine HCl, DS 103-282

Chemical Properties

Molecular Weight	290.17
Formula	C₉H₉Cl₂N₅S
Cas No.	64461-82-1
Smiles	Cl.Clc1c(NC2=NCCN2)c2nsnc2cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (155.08 mM), Sonication is recommended.

H2O: 29 mg/mL (99.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4463 mL	17.2313 mL	34.4626 mL	172.3128 mL
5 mM	0.6893 mL	3.4463 mL	6.8925 mL	34.4626 mL
10 mM	0.3446 mL	1.7231 mL	3.4463 mL	17.2313 mL
20 mM	0.1723 mL	0.8616 mL	1.7231 mL	8.6156 mL
50 mM	0.0689 mL	0.3446 mL	0.6893 mL	3.4463 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0345 mL	0.1723 mL	0.3446 mL	1.7231 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc