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(E/Z)-BCI
🥰Excellent
Catalog No. T11139Cas No. 15982-84-0
Alias NSC 150117
(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
(E/Z)-BCI
🥰Excellent
Purity: 99.94%
Catalog No. T11139Alias NSC 150117Cas No. 15982-84-0
(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $157 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $475 | In Stock | |
| 50 mg | $672 | In Stock | |
| 100 mg | $893 | In Stock | |
| 200 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $173 | In Stock |
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Purity:99.94%
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Product Introduction
Bioactivity
Chemical Properties
| Description | (E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
| In vitro | (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly reduces cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. Additionally, (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages, while also inhibiting cell proliferation, migration, and invasion in a receptor-independent manner, enhancing Cisplatin (CDDP) cytotoxicity, and promoting apoptosis in GC cells. Moreover, (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) significantly suppresses IL-1β, TNF-α, and IL-6 mRNA expression in LPS-activated macrophages, decreases ROS production, and activates the Nrf2 pathway. |
| In vivo | (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models. |
| Synonyms | NSC 150117 |
| Molecular Weight | 317.42 |
| Formula | C22H23NO |
| Cas No. | 15982-84-0 |
| Smiles | O=C1C(=Cc2ccccc2)C(NC2CCCCC2)c2ccccc12 |
| Relative Density. | 1.15 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 20 mg/mL (63.01 mM), Sonication is recommended. DMSO: 50 mg/mL (157.52 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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