Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1]. |
In vitro | Tubulin polymerization-IN-37 (also referred to as compound 2f), at a concentration of 1 μM for 72 hours, significantly reduces the proliferation of lymphoma cells by over 50%. At concentrations of 50 and 500 nM over 24 to 72 hours, this compound induces apoptosis and arrests VL51 and MINO cells in the G2/M phase of the cell cycle. Furthermore, at a concentration of 5 μM, it inhibits the binding of colchicine to tubulin by 80%, demonstrating its mechanism of action. Tubulin polymerization-IN-37 also exhibits cytotoxic effects against MCF-7 cells with an IC50 value of 0.21 μM. Additionally, in a cell proliferation assay involving VL51, MINO, HBL1, and SU-DHL-10 cell lines treated with 0-10 μM of the compound for 72 hours, cell proliferation was inhibited to 28.1%, 8.6%, 7.3%, and 13.8% at 1 μM, respectively, with IC50 values of 0.12, 0.07, 0.08, and 0.07 μM respectively. Cell cycle analysis further confirmed the compound's effectiveness in arresting VL51 and MINO cells in the G2/M phase at concentrations of 50 and 500 nM after 24, 48, and 72 hours of treatment. |
Molecular Weight | 340.37 |
Formula | C19H20N2O4 |
CAS No. | 2011784-92-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tubulin polymerization-IN-37 2011784-92-0 inhibitor inhibit