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Acapatamab
(Synonyms: AMG-160, AMG160, AMG 160) Copy Product Info
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Synonyms: AMG-160, AMG160, AMG 160
Catalog No. T9901A-097 Copy Product Info
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Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. Acapatamab (AMG-160) exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. Acapatamab (AMG-160) is utilized in cancer research.
Acapatamab
Cas No. 2314491-93-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $498 | - | In Stock | |
| 5 mg | $1,390 | - | In Stock | |
| 10 mg | $2,190 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.2% (SDS-PAGE); 96.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
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| Description | Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. Acapatamab (AMG-160) exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. Acapatamab (AMG-160) is utilized in cancer research. |
| Targets & IC50 | CD3 (human):22.4 nM (Kd), PSMA (human):14.8 nM (Kd) |
| In vitro | Acapatamab (AMG-160; 0-10000 pM; 48 h) induced activation in T cells and increased the expression of CD25, CD69, 4-1BB and PD-1. Under the same conditions, the effect of Acapatamab on T-cell leads to the release of dose-dependent cytokines, including IL-2, IL-4, IL-6, IL-10, IFNγ-γ and TNFα-α. In addition, Acapatamab (0-10000 pM; 48 h) Under the condition of co-culture with PBMC, PSMA positive prostate cancer cell line can be effectively lysed, and its EC 50 value is in the range of 6-42 pM. |
| In vivo | Administered intravenously on days 16, 23, and 31 at dosages of 0.02, 0.2, and 2 mg/kg, Acapatamab demonstrated antitumor properties by inhibiting the growth of CA prostate cancer xenograft tumors in NOD/SCID mice, specifically the 22Rv-1 CRPC model. |
| Synonyms | AMG-160, AMG160, AMG 160 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD3E & FOLH1 |
| Molecular Weight | 105.87 kDa |
| Cas No. | 2314491-93-3 |
| Isotype | Human IgG1-Fc |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Acapatamab in vivo | Acapatamab in vitro | Acapatamab molecular weight
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