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Acapatamab
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Catalog No. T9901A-097Cas No. 2314491-93-3
Alias AMG-160
Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research.
Acapatamab
Acapatamab
😃Good
Catalog No. T9901A-097Alias AMG-160Cas No. 2314491-93-3
Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $498 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $1,390 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $2,190 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Chemical Properties
| Description | Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research. |
| In vitro | Acapatamab (AMG-160; 0-10000 pM; 48 h) induces T cell activation characterized by increased expression of CD25, CD69, 4-1BB, and PD-1 in T cells. Additionally, Acapatamab at the same concentration and duration promotes a dose-dependent secretion of cytokines, including IL2, IL4, IL6, IL10, IFNγ, and TNFα when co-cultured with T-cells. Moreover, the compound effectively lyses prostate-specific membrane antigen (PSMA) positive prostate cancer cell lines when co-cultured with PBMCs, with an EC50 value of 6-42 pM. |
| In vivo | Administered intravenously on days 16, 23, and 31 at dosages of 0.02, 0.2, and 2 mg/kg, Acapatamab demonstrated antitumor properties by inhibiting the growth of CA prostate cancer xenograft tumors in NOD/SCID mice, specifically the 22Rv-1 CRPC model. |
| Synonyms | AMG-160 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Cas No. | 2314491-93-3 |
Storage & Solubility Information
| Storage | -20°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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