Anti-RET Antibody (1L221) (Synonyms: RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1|...)

Name: Anti-RET Antibody (1L221)
Brand: TargetMol
SKU: TMAY-02197
Rating: 4.5 (1 reviews)

Catalog No. TMAY-02197 Copy Product Info

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Anti-RET Antibody (1L221) is a Rabbit antibody targeting RET. Anti-RET Antibody (1L221) can be used in ELISA.

Anti-RET Antibody (1L221)

Copy Product Info

🥰Excellent

Catalog No. TMAY-02197

Synonyms RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12

Anti-RET Antibody (1L221) is a Rabbit antibody targeting RET. Anti-RET Antibody (1L221) can be used in ELISA.

Anti-RET Antibody
(1L221)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$269	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-RET Antibody (1L221) is a Rabbit antibody targeting RET. Anti-RET Antibody (1L221) can be used in ELISA.
Synonyms	RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12
Ig Type	Rabbit IgG
Clone	1L221
Reactivity	Human
Specificity	Human RET
Application	ELISA
Recommended Dose	ELISA: 1:5000-1:10000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human RET (rh RET; TMPY-02270; P07949-1; Met1-Arg635).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily, tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life; promotes the formation of Peyer's patch-like structures; modulates cell adhesion via its cleavage; involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand, triggering apoptosis. RET acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size; triggers the differentiation of rapidly adapting (RA) mechanoreceptors; mediated several diseases such as neuroendocrine cancers. Defects in RET may cause colorectal cancer, hirschsprung disease type 1, medullary thyroid carcinoma, multiple neoplasia type 2B, susceptibility to pheochromocytoma, multiple neoplasia type 2A, thyroid papillary carcinoma and congenital central hypoventilation syndrome.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human RET protein (TMPY-02270)
Antigen Species	Human
Biology Area	Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.