Shopping Cart

Your shopping cart is currently empty

ABBV-969 Payload

Name: ABBV-969 Payload
Brand: TargetMol
SKU: T74751
Price: 687 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T74751Cas No. 2857037-70-6

Alias Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

ABBV-969 Payload (Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT) is a drug-linker conjugate employed in the synthesis of antibody-drug conjugates (ADCs). The ABBV-969 Payload contains a Topoisomerase I inhibitor molecule and a chemical linker, enabling coupling with anti-c-Met antibodies to generate ABBV-969 ADCs with targeted anticancer activity.

ABBV-969 Payload

Copy Product Info

😃Good

Purity: 97.00%

Catalog No. T74751Alias Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPTCas No. 2857037-70-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$687	-	In Stock
5 mg	$1,680	-	In Stock
10 mg	$2,770	-	In Stock
25 mg	$4,120	-	In Stock
50 mg	$5,570	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.00%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ABBV-969 Payload (Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT) is a drug-linker conjugate employed in the synthesis of antibody-drug conjugates (ADCs). The ABBV-969 Payload contains a Topoisomerase I inhibitor molecule and a chemical linker, enabling coupling with anti-c-Met antibodies to generate ABBV-969 ADCs with targeted anticancer activity.
In vitro	ABBV-969 Payload forms an anti-c-Met topoisomerase 1 inhibitor antibody-drug conjugate (ADC) through conjugation with an anti-c-Met antibody.
Synonyms	Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

Chemical Properties

Molecular Weight	764.62
Formula	C₃₆H₃₈BrN₅O₉
Cas No.	2857037-70-6
Smiles	N(C([C@@H](NC([C@@H](NC(CBr)=O)[C@H](C)C)=O)C)=O)C12CC(C1)(C2)C3=C4C(C=5N(C4)C(=O)C6=C(C5)[C@](CC)(O)C(=O)OC6)=NC=7C3=CC8=C(C7)OCO8

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (104.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3078 mL	6.5392 mL	13.0784 mL	65.3920 mL
5 mM	0.2616 mL	1.3078 mL	2.6157 mL	13.0784 mL
10 mM	0.1308 mL	0.6539 mL	1.3078 mL	6.5392 mL
20 mM	0.0654 mL	0.3270 mL	0.6539 mL	3.2696 mL
50 mM	0.0262 mL	0.1308 mL	0.2616 mL	1.3078 mL
100 mM	0.0131 mL	0.0654 mL	0.1308 mL	0.6539 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc