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Ordesekimab

Catalog No. T76892 CAS 879293-15-9

Synonyms: AMG 714, PRV-015

Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interaction of IL-15 with the common gamma chain of the IL-2Rβ and IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab can be used to study non-reactive celiac disease (NRCD).

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Ordesekimab

Ordesekimab, CAS 879293-15-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 340.00
25 mg	In stock	$ 573.00
50 mg	In stock	$ 822.00

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Description	Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interaction of IL-15 with the common gamma chain of the IL-2Rβ and IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab can be used to study non-reactive celiac disease (NRCD).
In vitro	Theoretically, Ordesekimab (AMG 714) may promote antibody-dependent cell-mediated cytotoxicity (ADCC) by concurrently binding to Fcγ receptor (R) IIIα on natural killer (NK) cells and the IL-15/IL-15Rα complex on cells like monocytes, targeting cells expressing IL-15Rα[1].

Synonyms	AMG 714, PRV-015
Molecular Weight	N/A
CAS No.	879293-15-9

Storage

store at low temperature

store at -80°C

References and Literature

1. Yu-Ling Wei, et al. Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015). J Immunotoxicol. 2022 Dec;19(1):109-116.

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Keywords

Ordesekimab 879293-15-9 Immunology/Inflammation IL Receptor PRV015 AMG 714 AMG-714 PRV-015 PRV 015 AMG714 inhibitor inhibit

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