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LPA Receptor

Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include S1P receptors.

Edg-2 receptor inhibitor 1
T45211195941-38-8
Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
  • $98
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BMS-986278
T396472170126-74-4
BMS-986278 is an orally active and potent hemophosphatidic acid receptor 1 (LPA1) antagonist with Kb values of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively.BMS-986278 may be investigated for use in idiopathic pulmonary fibrosis.
  • $64
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LX-1031
T15796945976-76-1
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
  • $68
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1-Oleoyl lysophosphatidic acid sodium
T21654325465-93-8
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2
  • $64
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UCM-05194
T696472411412-36-5In house
UCM-05194 is a selective LPA1 receptor agonist that can improve neuropathic pain and can be used in the study of progressive system diseases.
  • $333
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DBIBB
T220701569309-92-7In house
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma rays on hematopoietic and gastrointestinal systems. It is an intermediate in organic synthesis and drug research. DBIBB can be used to prepare various compounds that reduce gastrointestinal radiation syndrome, increase intestinal crypt survival and intestinal cell proliferation, and reduce cell apoptosis.
  • $35
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LPA1 receptor antagonist 1
T157851396006-71-5In house
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis.
  • $147 TargetMol
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Radioprotectin-1
T126841622006-09-0In house
Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
  • $74
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H2L 5765834
T22834420841-84-5
H2L 5765834 is a lysophosphatidic acid receptors antagonist
  • $56
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AM966
T42781228690-19-4
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
  • $33
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Ki16425
T6108355025-24-0
Ki16425 (Debio 0719) is a competitive, potent, and reversible antagonist to LPA1, LPA2, and LPA3, with Ki values of 0.34 μM, 6.5 μM, and 0.93 μM, respectively.
  • $35
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BMS-986020
T40161257213-50-5
BMS-986020 (AM152) is a selective LPA1 antagonist.
  • $47
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TC LPA5 4
T234381393814-38-4
TC LPA5 4 is a LPA5 receptor antagonist.
  • $54
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LPA2 antagonist 2
T1187536840-10-5
LPA2 antagonist 2 is a selective and potent LPA2 antagonist (IC50: 28.3 nM) with potential anticancer activity, inhibits LPA3, and can be used in the study of cancer.
  • $97
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H2L5186303
T22835139262-76-3
H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
  • $30
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TAK-615
T96991664335-55-0
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
  • $69
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AM095 free acid
T102931228690-36-5
AM095 (free acid) is a potent LPA1 receptor antagonist with IC50 values of 0.98 μM for recombinant human LPA1 and 0.73 μM for recombinant mouse LPA1.
  • $33
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GRI977143
T22812325850-81-5
GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation.
  • $33
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Tetradecyl Phosphonate
T76894671-75-4
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
  • $50
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Ki16198
T6347355025-13-7
Ki16198 is an orally available LPA receptor antagonist and is a methyl ester derivative of Ki16425. It inhibits LPA1- and LPA3-induced inositol phosphates with Ki values of 0.34 and 0.93 μM, respectively, and can be used in studies of pancreatic carcinogenesis and metastasis.
  • $30
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AM095
T20001345614-59-6
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
  • $41
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ONO-7300243
T7393638132-34-0
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
  • $38
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ASP6432
T143351282549-08-9
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
  • $297
8-10 weeks
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