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BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc)

(Synonyms: Tumor necrosis factor receptor superfamily member 17, Tnfrsf17, CD269, Bcma, Bcm, B-cell maturation protein) Copy Product Info

Synonyms: Tumor necrosis factor receptor superfamily member 17, Tnfrsf17, CD269, Bcma, Bcm, B-cell maturation protein

Catalog No. TMPJ-01434 Copy Product Info
BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 38-45 KDa and the accession number is G7Q0I4.

Batch Information

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Purity:Greater than 95% as determined by reducing SDS-PAGE
Appearance:Lyophilized powder
Color:White
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Product Introduction

Bioactivity
Bioactivity
1. Loaded Human APRIL-His on HIS1K Biosensor, can bind Cynomolgus BCMA-Fc with an affinity constant of 0.54 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human APRIL -Flag-His at 1μg/ml (100 μl/well) can bind Cynomolgus BCMA-Fc. The ED50 of Cynomolgus BCMA-Fc is 4.23 ng/ml. (Regularly tested)
Description
BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 38-45 KDa and the accession number is G7Q0I4.
Species
Cynomolgus
Expression System
HEK293 Cells
TagC-hFc
Accession NumberG7Q0I4
Amino AcidMet1-Ala53
ConstructionMet1-Ala53
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsTumor necrosis factor receptor superfamily member 17, Tnfrsf17, CD269, Bcma, Bcm, B-cell maturation protein
Research Background
B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.
Chemical Properties
Molecular Weight38-45 KDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

Related Tags: BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) chemical structure | BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) molecular weight