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SNIPER(ABL)-039

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Catalog No. T18690Cas No. 2222354-29-0

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to an LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM for ABL, 10 nM for cIAP1, 12 nM for cIAP2, and 50 nM for XIAP[1].

SNIPER(ABL)-039

SNIPER(ABL)-039

😃Good
Catalog No. T18690Cas No. 2222354-29-0
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to an LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM for ABL, 10 nM for cIAP1, 12 nM for cIAP2, and 50 nM for XIAP[1].
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to an LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM for ABL, 10 nM for cIAP1, 12 nM for cIAP2, and 50 nM for XIAP[1].
Targets&IC50
Abl:0.54 nM (IC50), Abl:10 nM (DC50), CIAP2:12 nM (IC50), XIAP:50 nM (IC50), CIAP1:10 nM (IC50)
Chemical Properties
Molecular Weight1114.77
FormulaC54H68ClN11O9S2
Cas No.2222354-29-0
SmilesC([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(=O)N5CCN(CC5)C=6C=C(NC=7SC(C(NC8=C(C)C=CC=C8Cl)=O)=CN7)N=C(C)N6)=CC=C4)=CS3)[H]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

XIAP:50 nM (IC50)SNIPER(ABL)-039SNIPER(ABL)039SNIPER(ABL) 039SNIPERcIAP2:12 nM (IC50)cIAP1:10 nM (IC50)Abl:10 nM (DC50)Abl:0.54 nM (IC50)
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