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3-Deazaadenosine

Name: 3-Deazaadenosine
Brand: TargetMol
SKU: T10111L
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10111LCas No. 6736-58-9

3-Deazaadenosine (3-DAA) is a potent S-adenosylhomocysteine (SAH) hydrolase inhibitor. It inhibits methylation reactions by inducing intracellular SAH accumulation, exhibiting antiviral, anti-inflammatory, and immunomodulatory activities.

3-Deazaadenosine

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Catalog No. T10111LCas No. 6736-58-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	3-Deazaadenosine (3-DAA) is a potent S-adenosylhomocysteine (SAH) hydrolase inhibitor. It inhibits methylation reactions by inducing intracellular SAH accumulation, exhibiting antiviral, anti-inflammatory, and immunomodulatory activities.
Targets&IC50	HIV-1 (A018 isolate):0.20 μM, S-adenosylhomocysteine hydrolase:3.9 μM (Ki)
In vitro	3-Deazaadenosine dose-dependently inhibits viral replication (including HIV-1) by targeting SAH hydrolase to disrupt viral RNA methylation [1]. In macrophages, it suppresses NF-κB transcriptional activity and reduces pro-inflammatory cytokine (e.g., TNF-α) production [2]. Furthermore, it inhibits vascular smooth muscle cell proliferation by interfering with Ras prenylation and downstream signaling [3].
In vivo	In animal models of viral infection, treatment with 3-Deazaadenosine significantly reduces viral titers and improves survival rates [1]. In rodent models of vascular injury, systemic administration of 3-DAA effectively prevents neointima formation and inhibits the accumulation of inflammatory cells within the vessel wall, demonstrating its potential in managing proliferative vascular diseases [3].

Chemical Properties

Molecular Weight	266.25
Formula	C₁₁H₁₄N₄O₄
Cas No.	6736-58-9
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CC3)O[C@H](CO)[C@H]1O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (300.47 mM), Sonication is recommended.

DMSO: 100 mg/mL (375.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.4 mg/mL (9.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7559 mL	18.7793 mL	37.5587 mL	187.7934 mL
5 mM	0.7512 mL	3.7559 mL	7.5117 mL	37.5587 mL
10 mM	0.3756 mL	1.8779 mL	3.7559 mL	18.7793 mL
20 mM	0.1878 mL	0.9390 mL	1.8779 mL	9.3897 mL
50 mM	0.0751 mL	0.3756 mL	0.7512 mL	3.7559 mL
100 mM	0.0376 mL	0.1878 mL	0.3756 mL	1.8779 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc