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GPCR/G Protein

Cholecystokinin Receptor

Melanin-concentrating Hormone Receptor (MCHR)

(34)

Melanocortin Receptor

Neuropeptide FF Receptor

(9)

Neuropeptide W

(3)

Neuropeptide Y Receptor

Prostaglandin Receptor

(435)

Protease-activated Receptor

Succinate Receptor 1 (SUCNR1)

Amylin Receptor

The amylin receptors (AMYRs) are heterodimers of the calcitonin receptor that are bound to by amylin with high affinity and consist of AMY1, AMY2, and AMY3. Amylin mimetics that are agonists at the amylin receptors are being developed as therapies for diabetes and obesity. The AMY1 receptor may be activated by both amylin and the calcitonin gene-related peptide (CGRP) and could play a role in the effects of CGRP receptor antagonists developed for migraine. Dual agonists of the amylin and calcitonin receptors (DACRAs) are under development for obesity. Amylin and its receptors are believed to play a role in Alzheimer's disease.

Filter HomeSignaling PathwaysGPCR/G ProteinAmylin Receptor

Amylin, amide, rat acetate(124447-81-0,free base)

TP1232L

Amylin, amide, rat acetate is a potent and high affinity ligand of AMY1 and AMY3 receptors and variably of AMY2 receptors.

$178

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Amylin, amide, human

TP1183122384-88-7

Amylin, amide, human is a 37-amino acid peptide hormone co-secreted with insulin to regulate postprandial glucose levels, reducing glucagon secretion and delays gastric emptying. DAP Amide's tendency to aggregate into amyloid fibrils is associated with pancreatic β-cell damage in type 2 diabetes.

$166

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Amylin (1-37), human acetate

T76480L

Amylin (1-37), human acetate (hIAPP (1-37), acetate), a peptide hormone containing 37 amino acids secreted by the pancreas in conjunction with insulin, inhibits glucagon secretion and produces satiety during glucose homeostasis, and is a major component of amyloid deposits in the pancreas of patients with type 2 diabetes.

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Eloralintide sodium

TP3220

Eloralintide (LY 3841136) sodium is an AMYR agonist that shows promise for research in type 2 diabetes and obesity.

$195

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Amylin, amide, rat

TP1232124447-81-0

Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach, amylin caused a concentration-dependent decrease in ac

$213

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Pramlintide acetate(151126-32-8 free base)

TP2320187887-46-3

Pramlintide acetate, a polypeptide analogue of human amylin, functions as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.

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cAC 253 acetate

TP2135L

cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.

$195

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AC 187 Acetate

T21581L

AC 187 Acetate is a potent antagonist of amylin receptor .AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors.

$917

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Amylin (IAPP), feline

TP1519

Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.

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Petrelintide acetate

TP3039

Petrelintide (ZP8396) acetate is an amylin analog with potential for weight reduction, suitable for diabetes research.

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Colulintide

TP32522891912-36-8

Colulintide is an analog of amylin, utilized in obesity research.

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Pramlintide

T38998151126-32-8

Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.

$1,070

35 days

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Amylin (8-37), rat

TP1233138398-61-5

Amylin (8-37), rat, a truncated analog of native Amylin, selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin, also known as islet amyloid precursor peptide (IAPP), is co-secreted with insulin from pancreatic β-cells.

$211

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Eloralintide

TP30212883634-40-8

Eloralintide (LY 3841136) is an AMYR agonist, anticipated for research in type 2 diabetes and obesity.

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NI-203

T9901A-993

NI-203 is a monoclonal antibody inhibitor that targets amylin and shows potential for research in type 2 diabetes.

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Amylin (8-37), human

T38764135702-23-7

Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.

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AC 187 TFA

T75934

AC 187 TFA, a potent and orally active amylin receptor antagonist, exhibits an IC50 of 0.48 nM and a Ki of 0.275 nM. It demonstrates greater selectivity for the amylin receptor over calcitonin and CGRP receptors and has been shown to possess neuroprotective effects [1] [2].

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Amylin, amide, human TFA

T75787

Amylin, amide, human TFA, a 37-amino acid polypeptide, functions as a pancreatic hormone cosecreted with insulin, playing distinct roles in metabolism and glucose homeostasis by regulating blood sugar through inhibiting glucagon secretion, delaying gastric emptying, and promoting satiety [1].

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Pramlintide TFA

T75709

Pramlintide TFA, a polypeptide analogue of human amylin and an antidiabetic agent, exhibits antineoplastic properties in colorectal cancer [1].

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Amylin (8-37) (human)

T76478309244-90-4

Amylin (8-37) (human) (hIAPP (8-37)) is the 8-37 fragment of human islet amyloid polypeptide (IAPP) and exhibits a duplex folding with a hairpin structure [1].

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Acetyl-Amylin (8-37) (human)

T76645178603-79-7

Acetyl-Amylin (8-37) (human) is a specific amylin antagonist [1].

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Amylin (IAPP), feline TFA

T76028

Amylin (IAPP), feline TFA, a 37-amino acid polypeptide derived from felines, is a principal secretion product of the pancreatic islets' β-cells. This regulatory peptide notably inhibits the secretion of insulin and glucagon [1].

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Calcitonin (8-32), salmon

TP1677155069-90-2

Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist. Calcitonin, a hormone involved in calcium and phosphorus metabolism, is primarily produced by the parafollicular or C cells in the mammalian thyroid gland and is a 32 amino acid peptide cleaved from a larger prohormone.

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