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Diiodohydroxyquinoline
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Catalog No. T0513Cas No. 83-73-8
Alias Iodoquinol, 5,7-Diiodo-8-quinolinol, 5,7-Diiodo-8-hydroxyquinoline
Diiodohydroxyquinoline (Iodoquinol), a topical therapeutic agent, has satisfactory antibacterial properties.
Diiodohydroxyquinoline
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Purity: 97.74%
Catalog No. T0513Alias Iodoquinol, 5,7-Diiodo-8-quinolinol, 5,7-Diiodo-8-hydroxyquinolineCas No. 83-73-8
Diiodohydroxyquinoline (Iodoquinol), a topical therapeutic agent, has satisfactory antibacterial properties.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $30 | In Stock | In Stock | |
| 5 g | $56 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.74%
Appearance:Solid
Color:White
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Product Introduction
Diiodohydroxyquinoline AI Summary
Diiodohydroxyquinoline demonstrates a broad spectrum of bioactivities, indicating its potential as a versatile bioactive substance. It exhibits moderate to high potency as an inhibitor of various enzymes and pathways, including Lamin A Splicing, HSD17B4, JMJD2E, SMN2 Splice Variant Expression, TDP1, and ERK Signaling Pathway. Additionally, it shows potency in cell models for conditions such as Huntington's disease, Stat Signaling, Genomic imprint erasure, and Aldehyde Dehydrogenase 1 inhibition. Diiodohydroxyquinoline also affects cytotoxicity and cell viability in different cell lines, including HPDE-C7, HPDE-C7K, p53 mutant cancer cells, and during an influenza NS1 Protein Function assay.
Notably, it inhibits various protein functions such as 15-hLO, ROR gamma transcriptional activity, Menin-MLL Interaction, and Tyrosyl-DNA phosphodiesterase 1. The compound shows activity in inducing DNA re-replication, disrupting protein interactions, and inhibiting malarial parasite functions and cancer cells with p53 mutations. It also inhibits several kinases, including ERK1, ERK2, p38alpha, EGF Receptor, Fyn, ERBB2 (HER2), and LCK with varying IC50 values.
Moreover, Diiodohydroxyquinoline inhibits the OATP1B1 and OATP1B3 transporters, catechol-O-methyltransferase (COMT), and human BSEP. It shows antiviral activity against SARS-CoV-2 and antitrypanosomal activity against Trypanosoma brucei brucei. Additionally, it has antifungal activity against Candida albicans and Cryptococcus neoformans, antibacterial activity against Escherichia coli and other bacteria, and slight inhibition of human HDAC6 activity. The compound's solubility and permeability characteristics are suggested by its LogD7.4 value of 2.19, and it also shows haemolysis of human Red Blood Cells and cytotoxicity against HEK293 and HepG2 cells. Overall, Diiodohydroxyquinoline interacts with a variety of receptors and enzymes, suggesting its role as a multi-target bioactive compound..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Diiodohydroxyquinoline (Iodoquinol), a topical therapeutic agent, has satisfactory antibacterial properties. |
| Synonyms | Iodoquinol, 5,7-Diiodo-8-quinolinol, 5,7-Diiodo-8-hydroxyquinoline |
| Molecular Weight | 396.95 |
| Formula | C9H5I2NO |
| Cas No. | 83-73-8 |
| Smiles | Oc1c(I)cc(I)c2cccnc12 |
| Relative Density. | 2.3013 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 6.25 mg/mL (15.75 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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