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Benzyl nicotinate

Name: Benzyl nicotinate
Brand: TargetMol
SKU: T7713
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7713Cas No. 94-44-0

Alias Rubriment, Pycaril

Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor

Benzyl nicotinate

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Catalog No. T7713Alias Rubriment, PycarilCas No. 94-44-0

Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Liquid

Color:Transparent

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COA HNMR

Product Introduction

Benzyl nicotinate AI Summary

Benzyl nicotinate exhibits bioactivity related to membrane permeability and retention in various types of membranes, including IPM and silicon membranes. It has a dissociation constant (pKa) of 3.94 and demonstrates permeability in human skin, with log Kp values reported as -5.35 and -5.07, indicating low absorption through this route. The compound's effective permeability coefficients in different membrane compositions show log Pe values between -4.35 and -4.18 cm/s, including a log Pe value of -4.26 across a PAMPA membrane after 7 hours. Its partition coefficient (log P) of 2.4 indicates a balanced distribution between hydrophobic and hydrophilic phases. Additionally, Benzyl nicotinate shows bioactivity as an inhibitor in various assays, targeting enzymes and cellular processes such as Lamin A splicing modulators, MLL CXXC domain - DNA interaction inhibitors, tyrosyl-DNA phosphodiesterase (TDP1), Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), T. brucei phosphofructokinase, histone lysine methyltransferase G9a, delayed death inhibitors of the malarial parasite plastid, USP1/UAF1, Schwann cell PMP22 intronic element firefly luciferase assay, NPC, glutaminase (GLS), human TDP1, and GSK3B-pretreated cell viability. The compound also demonstrates cytotoxicity in various cell lines with reported IC50 values..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor
Synonyms	Rubriment, Pycaril

Chemical Properties

Molecular Weight	213.23
Formula	C₁₃H₁₁NO₂
Cas No.	94-44-0
Smiles	O=C(OCc1ccccc1)c1cccnc1
Relative Density.	1,1165 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (117.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6898 mL	23.4489 mL	46.8977 mL	234.4886 mL
5 mM	0.9380 mL	4.6898 mL	9.3795 mL	46.8977 mL
10 mM	0.4690 mL	2.3449 mL	4.6898 mL	23.4489 mL
20 mM	0.2345 mL	1.1724 mL	2.3449 mL	11.7244 mL
50 mM	0.0938 mL	0.4690 mL	0.9380 mL	4.6898 mL
100 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3449 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc