Anti-TIE2 Polyclonal Antibody

Name: Anti-TIE2 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01839
Rating: 4.5 (1 reviews)

(Synonyms: Tie-2, Tie2, TEK tyrosine kinase, endothelial, STK1, Hyk, Cd202b, AA517024) Copy Product Info

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Synonyms: Tie-2, Tie2, TEK tyrosine kinase, endothelial, STK1, Hyk, Cd202b, AA517024

Catalog No. TMAB-01839 Copy Product Info

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Anti-TIE2 Polyclonal Antibody is a Rabbit antibody targeting TIE2. Anti-TIE2 Polyclonal Antibody can be used in FCM, ICC/IF.

Anti-TIE2 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-TIE2 Polyclonal Antibody is a Rabbit antibody targeting TIE2. Anti-TIE2 Polyclonal Antibody can be used in FCM, ICC/IF.
Synonyms	Tie-2, Tie2, TEK tyrosine kinase, endothelial, STK1, Hyk, Cd202b, AA517024
Ig Type	IgG
Reactivity	Human (predicted:Mouse,Rat,Pig,Cow,Horse)

Application	FCM ICC/IF
Recommended Dose	FCM=3 μg/Test; ICC/IF=1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted.
Tissue Specificity	Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.TEK is closely related to the TIE receptor tyrosine kinase.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human Tie2
Antigen Species	Human
Gene Name	TEK
Gene ID	7010
Protein Name	Angiopoietin-1 receptor
Uniprot ID	Q02763
Biology Area	Endothelial Markers,Receptor Tyrosine Kinases,Angiogenesis and vasculogenesis,Endothelium,Endothelial Cells,Endothelial Cell Markers,Growth factor receptors
Function	This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.