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Anti-Mouse CD40L/CD154 Antibody (MR-1)
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Catalog No. T9901A-541 Copy Product Info
Purity: 95%
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Anti-Mouse CD40L/CD154 Antibody (MR-1) is a monoclonal inhibitory antibody targeting mouse CD40L/CD154. It downregulates the expression of the IFN signaling pathway and reduces IFN-β production, effectively prolonging graft survival. It can be used in research on cancer, inflammatory diseases, and xenotransplantation, including pancreatic cancer and autoimmune cholangitis.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $355 | - | In Stock | |
| 10 mg | $588 | - | In Stock | |
| 25 mg | $1,090 | - | In Stock | |
| 50 mg | $1,770 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | Anti-Mouse CD40L/CD154 Antibody (MR-1) is a monoclonal inhibitory antibody targeting mouse CD40L/CD154. It downregulates the expression of the IFN signaling pathway and reduces IFN-β production, effectively prolonging graft survival. It can be used in research on cancer, inflammatory diseases, and xenotransplantation, including pancreatic cancer and autoimmune cholangitis. |
| In vitro | Anti-Mouse CD40L/CD154 Antibody (MR-1) significantly inhibits IFN-β production in natural killer T (NKT) cells when treated at 200 μg/mL for 48 hours [1]. |
| In vivo | Anti-Mouse CD40L/CD154 Antibody (MR-1) administered intraperitoneally at a dose of 500 μg every 2 days from 2 days before tumor inoculation to 12 days after inoculation significantly downregulates the expression of type I IFN signaling pathway-related genes in male C57BL/6J mice bearing KPC1242 tumors [1]. Anti-Mouse CD40L/CD154 Antibody (MR-1) administered intraperitoneally at 20 mg/kg once daily for 4 days starting 1 day before surgery, and then once weekly until the end of the experiment, prolongs the survival time of human neural stem cells (hNSCs) in 5XFAD transgenic mice [2]. Anti-Mouse CD40L/CD154 Antibody (MR-1) administered intraperitoneally at 25 mg/kg on days 0, 2, 4, and 7 as initial doses, followed by once-weekly maintenance doses, temporarily delays the progression of cholangitis in dnTGFβRII mice [3]. |
| Clone | MR-1 |
| Reactivity | Mouse |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD40L/CD154 |
| Molecular Weight | 150 kDa |
| Isotype | Mouse IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Anti-Mouse CD40L/CD154 Antibody (MR-1) chemical structure | Anti-Mouse CD40L/CD154 Antibody (MR-1) in vivo | Anti-Mouse CD40L/CD154 Antibody (MR-1) in vitro | Anti-Mouse CD40L/CD154 Antibody (MR-1) molecular weight
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