Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Melatonin Receptor

Melatonin receptors are a group of high affinity Gi/G0 protein-coupled receptors, which are split into two subtypes; MT1 and MT2.

Agomelatine
T1445138112-76-2
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
  • $57
In Stock
Size
QTY
6-Chloromelatonin
T2253063762-74-3In house
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.
  • $350
In Stock
Size
QTY
Luzindole
T15795117946-91-5
Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1.
  • $47
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Ramelteon
T1463196597-26-9
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
  • $37
In Stock
Size
QTY
4-P-PDOT
T14042134865-74-0
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
2-Iodomelatonin
T1007393515-00-5In house
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2. It can be used to identify, characterize, and localize melatonin binding sites in the brain and peripheral tissues.
  • $38
In Stock
Size
QTY
Tasimelteon
T3495609799-22-6
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
  • $38
In Stock
Size
QTY
ACH-000143
T91932225836-30-4
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
  • $48
In Stock
Size
QTY
UCM 608
T22499151889-03-1
UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.
  • $46
In Stock
Size
QTY
N-ACETYLTRYPTAMINE
T86001016-47-3
N-ACETYLTRYPTAMINE is a partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase.
  • $37
In Stock
Size
QTY