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Diclofenac Acyl Glucuronide

Name: Diclofenac Acyl Glucuronide
Brand: TargetMol
SKU: T27167
Rating: 4.5 (1 reviews)

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Catalog No. T27167Cas No. 64118-81-6

Alias Diclofenac Acyl-β-D-Glucuronide, D-1-O-G

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.

Diclofenac Acyl Glucuronide

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Purity: 95%

Catalog No. T27167Alias Diclofenac Acyl-β-D-Glucuronide, D-1-O-GCas No. 64118-81-6

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,099	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.
Targets&IC50	OAT3 (human, HEK293):292 ± 38.1 μM, Mock (HEK293):519 ± 55.3 μM, OAT1 (human, HEK293):239 ± 20.6 μM
In vitro	Cytotoxicity and the intracellular accumulation of diclofenac acyl glucuronide were evaluated in the absence or presence of cilastatin using hOAT1/3‐transfected cells. After incubation of diclofenac acyl glucuronide for 24 hr, the survival rate of hOAT1/3‐HEK293 cells was significantly lower than that in mock‐HEK293 cells, and the IC50 values of diclofenac acyl glucuronide in hOAT1/3‐HEK293 cells were only approximately half of that in mock‐HEK293 cells[1].
In vivo	Cilastatin increased the plasma concentration and decreased the renal distribution of diclofenac acyl glucuronide in mice. Diclofenac (200 mg·kg−1) was orally administered to mice. The AUC(0–12 hr) of diclofenac acyl glucuronide in plasma was increased by 46.7%, while the AUC(0–12 hr) in the kidney. [1]
Synonyms	Diclofenac Acyl-β-D-Glucuronide, D-1-O-G

Chemical Properties

Molecular Weight	472.27
Formula	C₂₀H₁₉Cl₂NO₈
Cas No.	64118-81-6
Smiles	N(C1=C(CC(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)C=CC=C1)C3=C(Cl)C=CC=C3Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc