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Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $1,099 | 35 days |
Description | Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers. |
Targets&IC50 | OAT3 (human, HEK293):292 ± 38.1 μM, Mock (HEK293):519 ± 55.3 μM, OAT1 (human, HEK293):239 ± 20.6 μM |
In vitro | Cytotoxicity and the intracellular accumulation of diclofenac acyl glucuronide were evaluated in the absence or presence of cilastatin using hOAT1/3‐transfected cells. After incubation of diclofenac acyl glucuronide for 24 hr, the survival rate of hOAT1/3‐HEK293 cells was significantly lower than that in mock‐HEK293 cells, and the IC50 values of diclofenac acyl glucuronide in hOAT1/3‐HEK293 cells were only approximately half of that in mock‐HEK293 cells[1]. |
In vivo | Cilastatin increased the plasma concentration and decreased the renal distribution of diclofenac acyl glucuronide in mice. Diclofenac (200 mg·kg−1) was orally administered to mice. The AUC(0–12 hr) of diclofenac acyl glucuronide in plasma was increased by 46.7%, while the AUC(0–12 hr) in the kidney. [1] |
Alias | Diclofenac Acyl-β-D-Glucuronide, D-1-O-G |
Molecular Weight | 472.27 |
Formula | C20H19Cl2NO8 |
Cas No. | 64118-81-6 |
Smiles | N(C1=C(CC(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)C=CC=C1)C3=C(Cl)C=CC=C3Cl |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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