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Diclofenac Acyl Glucuronide

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Catalog No. T27167Cas No. 64118-81-6
Alias Diclofenac Acyl-β-D-Glucuronide, D-1-O-G

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.

Diclofenac Acyl Glucuronide

Diclofenac Acyl Glucuronide

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Purity: 95%
Catalog No. T27167Alias Diclofenac Acyl-β-D-Glucuronide, D-1-O-GCas No. 64118-81-6
Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.
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1 mg$1,09935 days
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Purity:95%
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Product Introduction

Bioactivity
Description
Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.
Targets&IC50
OAT3 (human, HEK293):292 ± 38.1 μM, Mock (HEK293):519 ± 55.3 μM, OAT1 (human, HEK293):239 ± 20.6 μM
In vitro
Cytotoxicity and the intracellular accumulation of diclofenac acyl glucuronide were evaluated in the absence or presence of cilastatin using hOAT1/3‐transfected cells. After incubation of diclofenac acyl glucuronide for 24 hr, the survival rate of hOAT1/3‐HEK293 cells was significantly lower than that in mock‐HEK293 cells, and the IC50 values of diclofenac acyl glucuronide in hOAT1/3‐HEK293 cells were only approximately half of that in mock‐HEK293 cells[1].
In vivo
Cilastatin increased the plasma concentration and decreased the renal distribution of diclofenac acyl glucuronide in mice. Diclofenac (200 mg·kg−1) was orally administered to mice. The AUC(0–12 hr) of diclofenac acyl glucuronide in plasma was increased by 46.7%, while the AUC(0–12 hr) in the kidney. [1]
AliasDiclofenac Acyl-β-D-Glucuronide, D-1-O-G
Chemical Properties
Molecular Weight472.27
FormulaC20H19Cl2NO8
Cas No.64118-81-6
SmilesN(C1=C(CC(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)C=CC=C1)C3=C(Cl)C=CC=C3Cl
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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