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JNJ-2901
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Catalog No. T206130Cas No. 2059985-55-4
JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. It effectively reduces bacterial load in acute and chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 is useful for tuberculosis (TB) research.
JNJ-2901
Copy Product Info😃Good
Catalog No. T206130Cas No. 2059985-55-4
JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. It effectively reduces bacterial load in acute and chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 is useful for tuberculosis (TB) research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. It effectively reduces bacterial load in acute and chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 is useful for tuberculosis (TB) research. |
| In vitro | JNJ-2901, at concentrations ranging from 0.005 µM to 5 mM over 5 days, inhibits the growth of M. tuberculosis H37Rv-ΔcydAB in 7H9 medium, with an MIC of 2.5 nM. It also suppresses the oxygen consumption of wild-type M. smegmatis (IC 50: 89 nM) and the cytochrome bd knockout strain (ΔcydAB) (IC 50: 60 nM), while showing no significant effect on the cytochrome bc knockout strain (ΔqcrCAB). Additionally, JNJ-2901 inhibits oxygen consumption in M. smegmatis with Mtb-like cytochrome bc (IC 50: 17.4 nM). |
| In vivo | JNJ-2901 (10 mg/kg, subcutaneous injection, administered for 12 days over 8 weeks) has been demonstrated to reduce the bacterial load (3.6-log/4.0-log) in both acute and chronic M. tuberculosis H37Rv-ΔcydAB infection models in 6-8 week-old female Balb/cBy mice. |
| Molecular Weight | 540.986 |
| Formula | C24H24ClF3N4O3S |
| Cas No. | 2059985-55-4 |
| Smiles | O=C(NCC1=CC=C(C=C1)C2CC3(CN(C3)S(=O)(=O)C(F)(F)F)C2)C4=C(N=C5C=CC(Cl)=CN54)CC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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