Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Sodium 4-phenylbutyrate

Sodium 4-phenylbutyrate
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
Catalog No. T1535Cas No. 1716-12-7
Select Batch
Purity:100%
Contact us for more batch information

Resource Download

Sodium 4-phenylbutyrate

Catalog No. T1535Cas No. 1716-12-7

Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
50 mg$38In Stock
100 mg$54In Stock
200 mg$87In Stock
500 mg$144In Stock
1 mL x 10 mM (in DMSO)$50In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Sodium 4-phenylbutyrate"

Product Introduction

Bioactivity
Description
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
In vitro
In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.
In vivo
In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.
AliasSodium Phenylbutyrate, Buphenyl, TriButyrate
Chemical Properties
Molecular Weight186.18
FormulaC10H11NaO2
Cas No.1716-12-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 18.6 mg/mL (100 mM)
DMSO: 50 mg/mL (268.56 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.3711 mL26.8557 mL53.7115 mL268.5573 mL
5 mM1.0742 mL5.3711 mL10.7423 mL53.7115 mL
10 mM0.5371 mL2.6856 mL5.3711 mL26.8557 mL
20 mM0.2686 mL1.3428 mL2.6856 mL13.4279 mL
50 mM0.1074 mL0.5371 mL1.0742 mL5.3711 mL
100 mM0.0537 mL0.2686 mL0.5371 mL2.6856 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Sodium 4-phenylbutyrate | purchase Sodium 4-phenylbutyrate | Sodium 4-phenylbutyrate cost | order Sodium 4-phenylbutyrate | Sodium 4-phenylbutyrate chemical structure | Sodium 4-phenylbutyrate in vivo | Sodium 4-phenylbutyrate in vitro | Sodium 4-phenylbutyrate formula | Sodium 4-phenylbutyrate molecular weight