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Calmidazolium chloride

Name: Calmidazolium chloride
Brand: TargetMol
SKU: T10667
Price: 57 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10667Cas No. 57265-65-3

Alias R 24571

Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.

Calmidazolium chloride

🥰Excellent

Purity: 98.53%

Catalog No. T10667Alias R 24571Cas No. 57265-65-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$57	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$226	In Stock	In Stock
100 mg	$337	In Stock	In Stock
200 mg	$491	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.53%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
Targets&IC50	Calmodulin:12.69 μM(mouse E14 ESCs), Calmodulin:3 nM(kd), Calmodulin:8.18 μM(mouse F9 ECCs), PDE (CaM-dependent):0.15 μM, Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM
In vitro	Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2].
Synonyms	R 24571

Chemical Properties

Molecular Weight	687.7
Formula	C₃₁H₂₃Cl₇N₂O
Cas No.	57265-65-3
Smiles	[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (348.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4541 mL	7.2706 mL	14.5412 mL	72.7061 mL
5 mM	0.2908 mL	1.4541 mL	2.9082 mL	14.5412 mL
10 mM	0.1454 mL	0.7271 mL	1.4541 mL	7.2706 mL
20 mM	0.0727 mL	0.3635 mL	0.7271 mL	3.6353 mL
50 mM	0.0291 mL	0.1454 mL	0.2908 mL	1.4541 mL
100 mM	0.0145 mL	0.0727 mL	0.1454 mL	0.7271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc