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Calmidazolium chloride

Name: Calmidazolium chloride
Brand: TargetMol
SKU: T10667
Price: 57 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10667Cas No. 57265-65-3

Alias R 24571

Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.

Calmidazolium chloride

🥰Excellent

Purity: 98.53%

Catalog No. T10667Alias R 24571Cas No. 57265-65-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$57	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$226	In Stock	In Stock
100 mg	$337	In Stock	In Stock
200 mg	$491	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.53%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
Targets&IC50	Calmodulin:3 nM(kd), Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM, Calmodulin:12.69 μM(mouse E14 ESCs), PDE (CaM-dependent):0.15 μM, Calmodulin:8.18 μM(mouse F9 ECCs)
In vitro	Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2].
Synonyms	R 24571

Chemical Properties

Molecular Weight	687.7
Formula	C₃₁H₂₃Cl₇N₂O
Cas No.	57265-65-3
Smiles	[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (145.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.8 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4541 mL	7.2706 mL	14.5412 mL	72.7061 mL
5 mM	0.2908 mL	1.4541 mL	2.9082 mL	14.5412 mL
10 mM	0.1454 mL	0.7271 mL	1.4541 mL	7.2706 mL
20 mM	0.0727 mL	0.3635 mL	0.7271 mL	3.6353 mL
50 mM	0.0291 mL	0.1454 mL	0.2908 mL	1.4541 mL
100 mM	0.0145 mL	0.0727 mL	0.1454 mL	0.7271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc