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Calmidazolium chloride

🥰Excellent
Catalog No. T10667Cas No. 57265-65-3
Alias R 24571

Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.

Calmidazolium chloride

Calmidazolium chloride

🥰Excellent
Purity: 98.53%
Catalog No. T10667Alias R 24571Cas No. 57265-65-3
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
Pack SizePriceAvailabilityQuantity
5 mg$57In Stock
10 mg$89In Stock
25 mg$148In Stock
50 mg$226In Stock
100 mg$337In Stock
200 mg$491In Stock
1 mL x 10 mM (in DMSO)$87In Stock
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Purity:98.53%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
Targets&IC50
Calmodulin:3 nM(kd), Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM, Calmodulin:12.69 μM(mouse E14 ESCs), Calmodulin:8.18 μM(mouse F9 ECCs), PDE (CaM-dependent):0.15 μM
In vitro
Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2].
SynonymsR 24571
Chemical Properties
Molecular Weight687.7
FormulaC31H23Cl7N2O
Cas No.57265-65-3
Smiles[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (145.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4541 mL7.2706 mL14.5412 mL72.7061 mL
5 mM0.2908 mL1.4541 mL2.9082 mL14.5412 mL
10 mM0.1454 mL0.7271 mL1.4541 mL7.2706 mL
20 mM0.0727 mL0.3635 mL0.7271 mL3.6353 mL
50 mM0.0291 mL0.1454 mL0.2908 mL1.4541 mL
100 mM0.0145 mL0.0727 mL0.1454 mL0.7271 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

R-24571R24571InhibitorinhibitCaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesCalmodulincalmodulinCalmidazolium ChlorideCalmidazolium chlorideCalmidazoliumAutophagy
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