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2-Cyanopyrimidine

Name: 2-Cyanopyrimidine
Brand: TargetMol
SKU: T7451
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7451Cas No. 14080-23-0

Alias 2-cyano-Pyrimidine

2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)

2-Cyanopyrimidine

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Purity: 99.27%

Catalog No. T7451Alias 2-cyano-PyrimidineCas No. 14080-23-0

2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.27%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

2-Cyanopyrimidine AI Summary

2-Cyanopyrimidine shows reactivity with glutathione (GSH), with a reaction rate constant (K) of 23.0 x 10^-3/min at 37°C and a reaction half-life (T1/2) of 0.5 hours at pH 7.4. As per additional analyses, the thiol reactivity rate constant is 0.3138 at a 250 µM concentration over 72 hours, and it demonstrates a half-life for glutathione reactivity of 2.2 hours, indicating moderate reactivity and reasonable stability with a degradation half-life greater than 1 hour. The compound exhibits antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 6.03% at a 10 µM concentration after 48 hours and showing a 0.09% inhibition rate in VERO-6 cells under similar conditions. Additionally, 2-Cyanopyrimidine acts as a SARS-CoV-2 3CL-Pro protease inhibitor with an 11.18% inhibition at 20 µM concentration. It also presents inhibitory activity against human HDAC6 with minimal inhibitory effects of -1.21% and -1.57% in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)
Targets&IC50	Cathepsin:170 nM
Synonyms	2-cyano-Pyrimidine

Chemical Properties

Molecular Weight	105.1
Formula	C₅H₃N₃
Cas No.	14080-23-0
Smiles	N#CC1=NC=CC=N1
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (104.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.5147 mL	47.5737 mL	95.1475 mL	475.7374 mL
5 mM	1.9029 mL	9.5147 mL	19.0295 mL	95.1475 mL
10 mM	0.9515 mL	4.7574 mL	9.5147 mL	47.5737 mL
20 mM	0.4757 mL	2.3787 mL	4.7574 mL	23.7869 mL
50 mM	0.1903 mL	0.9515 mL	1.9029 mL	9.5147 mL
100 mM	0.0951 mL	0.4757 mL	0.9515 mL	4.7574 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc