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2-Cyanopyrimidine

Name: 2-Cyanopyrimidine
Brand: TargetMol
SKU: T7451
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7451Cas No. 14080-23-0

Alias 2-cyano-Pyrimidine

2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)

2-Cyanopyrimidine

🥰Excellent

Purity: 99.27%

Catalog No. T7451Alias 2-cyano-PyrimidineCas No. 14080-23-0

2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)

Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.27%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)
Targets&IC50	Cathepsin:170 nM
Synonyms	2-cyano-Pyrimidine

Chemical Properties

Molecular Weight	105.1
Formula	C₅H₃N₃
Cas No.	14080-23-0
Smiles	N#CC1=NC=CC=N1
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (104.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.5147 mL	47.5737 mL	95.1475 mL	475.7374 mL
5 mM	1.9029 mL	9.5147 mL	19.0295 mL	95.1475 mL
10 mM	0.9515 mL	4.7574 mL	9.5147 mL	47.5737 mL
20 mM	0.4757 mL	2.3787 mL	4.7574 mL	23.7869 mL
50 mM	0.1903 mL	0.9515 mL	1.9029 mL	9.5147 mL
100 mM	0.0951 mL	0.4757 mL	0.9515 mL	4.7574 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc