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AG-13958
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Catalog No. T7493Cas No. 319460-94-1
Alias AG-013958
AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.
AG-13958
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Purity: 99.4%
Catalog No. T7493Alias AG-013958Cas No. 319460-94-1
AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | In Stock | In Stock | |
| 5 mg | $278 | In Stock | In Stock | |
| 10 mg | $428 | In Stock | In Stock | |
| 25 mg | $689 | In Stock | In Stock | |
| 50 mg | $993 | In Stock | In Stock | |
| 100 mg | $1,320 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $289 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.4%
Appearance:Solid
Color:White
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Product Introduction
AG-13958 AI Summary
AG-13958 exhibits potent inhibition with a Ki of 0.04 nM against the unphosphorylated human 50 residues truncated cytoplasmic domain of VEGFR2 E990V mutant. It moderately inhibits the N-terminal truncated form of phosphorylated LCK P233M/C224D mutant with an inhibition rate of 11.0%. Furthermore, it shows a moderate inhibitory effect on the human phosphorylated FGFR1 L457V/C488A/C584S mutant with a Ki of 79.0 nM. This compound demonstrates strong antiproliferative activity, achieving IC50 values of 4.0 nM against VEGF-stimulated HUVEC cells and 8.4 nM against VEGF-stimulated human MV522 cells. Additionally, it exhibits significant antivascular activity, causing 54.0% vessel regression in a rat model of retinopathy when administered intravitreally at a concentration of 5 mg/ml. Pharmacokinetic analysis in B6 mice reveals an AUClast of 712.0 ng·hr·mL^-1, a Cmax of 731.54 nM, and a Cmin of 15.0 ng/ml at a dose of 25 mg/kg administered orally..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration. |
| Synonyms | AG-013958 |
| Molecular Weight | 467.5 |
| Formula | C26H22FN7O |
| Cas No. | 319460-94-1 |
| Smiles | Cc1cnn(C)c1C(=O)Nc1cc(Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)ccc1F |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (10.7 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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