store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 198.00 | |
2 mg | In stock | $ 268.00 | |
5 mg | In stock | $ 388.00 | |
10 mg | In stock | $ 629.00 | |
25 mg | In stock | $ 1,180.00 | |
50 mg | In stock | $ 1,790.00 | |
100 mg | In stock | $ 2,320.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 448.00 |
Description | I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells. |
In vitro | I-138 (0.5 μM; 4 hours) eliminates HAP-1 USP1 WT and knockout cells' USP1 autodeubiquitination[1]. I-138 (0.5 μM; 4 hours) induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells[1].I-138 (0.01-10 μM; 10 days) dose-dependently inhibits the viability of MDA-MB-436 cells without affecting HCC1954 cells[1]. |
In vivo | I-138 (50 mg/kg/day; oral administration; for 41 days) exhibits USP1 inhibition and moderate antitumor activity in mice carrying MDA-MB-436 tumors. However, the combination of I-138 and the PARP inhibitor Niraparib is more effective in inhibiting BRCA1/2 mutant tumors in vivo[1]. |
Molecular Weight | 492.5 |
Formula | C26H23F3N6O |
CAS No. | 2098211-50-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (162.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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I-138 2098211-50-6 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibitor inhibit