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Anti-CYP8B1 Polyclonal Antibody
(Synonyms: Sterol 12-alpha-hydroxylase, Cytochrome P450, family 8, subfamily B, polypeptide 1, Cytochrome P450 8B1, CYPVIIIB1, CYP8B1, CYP12, CP8B1, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase) Copy Product Info
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Synonyms: Sterol 12-alpha-hydroxylase, Cytochrome P450, family 8, subfamily B, polypeptide 1, Cytochrome P450 8B1, CYPVIIIB1, CYP8B1, CYP12, CP8B1, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase
Catalog No. TMAB-00528 Copy Product Info
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Anti-CYP8B1 Polyclonal Antibody is a Rabbit antibody targeting CYP8B1. Anti-CYP8B1 Polyclonal Antibody can be used in WB.
Anti-CYP8B1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $220 | 7-10 days | 7-10 days | |
| 100 µL | $374 | 7-10 days | 7-10 days | |
| 200 µL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CYP8B1 Polyclonal Antibody is a Rabbit antibody targeting CYP8B1. Anti-CYP8B1 Polyclonal Antibody can be used in WB. |
| Synonyms | Sterol 12-alpha-hydroxylase, Cytochrome P450, family 8, subfamily B, polypeptide 1, Cytochrome P450 8B1, CYPVIIIB1, CYP8B1, CYP12, CP8B1, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | Sample: Lane 1: Recombinant human CYP8B1 protein Primary: Anti-CYP8B1 (TMAB-00528) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kDa Observed band size: 55 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
| Tissue Specificity | Liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human CYP8B1 |
| Antigen Species | Human |
| Gene Name | CYP8B1 |
| Gene ID | |
| Protein Name | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
| Uniprot ID | |
| Biology Area | Lipid metabolism,Cytochromes,Lipases,Cytochromes |
| Function | Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids. |
| Molecular Weight | Theoretical: 58 kDa. Actual: 55 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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