Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 465.00 | |
500 μg | 5 days | $ 1,850.00 | |
1 mg | 5 days | $ 3,100.00 |
Description | Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. |
Species | Mouse |
Expression System | HEK293 |
Tag | C-hFc |
Accession Number | O88593 |
Synonyms | PGRPSMGC126896, TNFSF3L, PGLYRP1, TAG7, PGLYRP, PGRP, PGRP-SMGC126894, PGRP-S, Tasg7 |
Construction | Recombinant Mouse PGLYRP1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Phe19-Glu182.[Accession |O88593] |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | The protein has a predicted MW of 45.7 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Supplied as 0.22μm filtered solution in PBS, 10% Glycerol (pH 8.0). |
Stability & Storage |
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. |
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Please read the User Guide of Recombinant Proteins for more specific information.
PGLYRP1 Protein, Mouse, Recombinant (hFc) PGRPSMGC 126896 PGLYRP 1 PGRP-SMGC 126894 PGRPSMGC126896 TNFSF3L PGLYRP1 PGRPSMGC-126896 PGRP-SMGC-126894 TAG-7 PGLYRP-1 TAG7 PGLYRP PGRP PGRP-SMGC126894 PGRP-S TAG 7 Tasg7 recombinant recombinant-proteins proteins protein