Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1. Moreover, WRR139 amplifies the cytotoxic effects of Carfilzomib on cancer cells [1].
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Description | WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1. Moreover, WRR139 amplifies the cytotoxic effects of Carfilzomib on cancer cells [1]. |
In vitro | WRR139 (0.01-100 μM; 1 hour) inhibits NGLY1 and impairs the processing of Nrf1 in HEK293 cells in vitro [1]. At a concentration of 5 μM and an exposure time of 18 hours, WRR139 disrupts the processing, localization, and activation of Nrf1 in HEK293 cells [1]. Furthermore, WRR139 (1 μM; 24 hours) enhances the cytotoxicity of Carfilzomib in U266, H929, and Jurkat cells in an NGLY1-dependent manner [1]. |
Molecular Weight | 456.6 |
Formula | C25H32N2O4S |
CAS No. | 2138924-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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WRR139 2138924-36-2 inhibitor inhibit