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CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)

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Catalog No. TP1501L

CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.

CTTHWGFTLC, CYCLIC acetate(244082-19-7  free base)

CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)

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Purity: 99.71%
Catalog No. TP1501L
CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$79In StockIn Stock
5 mg$185In StockIn Stock
10 mg$352In StockIn Stock
25 mg$563In StockIn Stock
50 mg$768In StockIn Stock
100 mg$1,030In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.
Chemical Properties
Molecular Weight1226.39
FormulaC54H75N13O16S2
SmilesC[C@@H](O)[C@H]1C(N[C@@H]([C@H](O)C)C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CNC4=CC=CC=C43)C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CSSC[C@H](N)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.no data available
SequenceH-Cys(1)-Thr-xiThr-DL-His-Trp-Gly-Phe-DL-Thr-DL-Leu-Cys(1)-OH
Sequence ShortCTXHWGFTLC
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8154 mL4.0770 mL8.1540 mL40.7701 mL
5 mM0.1631 mL0.8154 mL1.6308 mL8.1540 mL
10 mM0.0815 mL0.4077 mL0.8154 mL4.0770 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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