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Isoflavone

Name: Isoflavone
Brand: TargetMol
SKU: T8194
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8194Cas No. 574-12-9

Isoflavones possess antioxidant properties and antipromotional effects.

Isoflavone

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Catalog No. T8194Cas No. 574-12-9

Isoflavones possess antioxidant properties and antipromotional effects.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$37	In Stock	In Stock
1 g	$50	In Stock	In Stock
5 g	$118	-	In Stock
10 g	$173	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Orange

Resource Download

COA LCMS

Product Introduction

Isoflavone AI Summary

Isoflavone shows gastroprotective activity in a rat ethanol-induced damage model following intraperitoneal administration, providing less than 10.0% protection. It also exhibits antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294, inhibiting microbial growth at 10 uM after 5 to 8 days using the MABA method, with 0.0% growth inhibition. Furthermore, Isoflavone demonstrates antiproliferative activity against various human cell lines (A549, MDA-MB-231, MCF7, KB, and KB-VIN) with an IC50 value greater than 10,000.0 nM, indicating low potency. Additionally, it inhibits CYP450 in human liver microsomes, specifically the formation of 20-HETE and EpETrE at 10 uM in the presence of arachidonic acid and NADPH, with less than 15.0% inhibition and a selectivity index log ratio of 0.19 between the inhibition of EpETrE and 20-HETE formation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Isoflavones possess antioxidant properties and antipromotional effects.

Chemical Properties

Molecular Weight	222.24
Formula	C₁₅H₁₀O₂
Cas No.	574-12-9
Smiles	O=c1c(coc2ccccc12)-c1ccccc1
Relative Density.	1.239 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (292.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4996 mL	22.4982 mL	44.9964 mL	224.9820 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL	44.9964 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL	22.4982 mL
20 mM	0.2250 mL	1.1249 mL	2.2498 mL	11.2491 mL
50 mM	0.0900 mL	0.4500 mL	0.8999 mL	4.4996 mL
100 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc